 |
|
Results of a Randomized Feasibility Study of a Low-Fat Diet
William Insull, Jr, MD;
Maureen M. Henderson, MD, DrPH;
Ross L. Prentice, PhD;
Donovan J. Thompson, PhD;
Carolyn Clifford, PhD;
Susan Goldman, RD;
Sherwood Gorbach, MD;
Myron Moskowitz, MD;
Robert Thompson, MD;
Margo Woods, ScD
Arch Intern Med. 1990;150(2):421-427.
Abstract
| |
• A 2-year randomized clinical trial was conducted to test whether free-living women aged 45 to 69 years can reduce the fat content of their diet from the typical US level of approximately 39% to 20% of energy from fat, using readily available foods, when given nutritional and behavioral counseling and social support. Three clinical units randomized 303 selected volunteers into intervention (low-fat eating plan) or control (customary diet) groups. The two groups were comparable at baseline. The intervention group received nutrition instruction and behavioral counseling largely in permanent groups of 12 to 15 participants meeting weekly, then biweekly, and finally monthly. At 6 months, they had substantially reduced the mean proportion of total energy from fat from 39.1% to 20.9%, compared with the control group's nonsignificant reduction from 39.0% to 38.1%. At 12 and 24 months, they sustained the reduction of energy from fat. Weight loss and plasma cholesterol level changes in the intervention group supported the self-recorded dietary intake changes. Attendance at intervention sessions averaged 75% during the first 6 months and, subsequently, 60% to 70%. Fourday food records for the randomized women were obtained at 6 and 12 months from approximately 95% and at 24 months from 87%. A clinical trial of a low-fat diet is feasible in women.
(Arch Intern Med. 1909;150:421-427)
Author Affiliations
From the Department of Medicine, The Methodist Hospital and Baylor College of Medicine, Houston, Tex (Dr Insull); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash (Drs Henderson, Prentice, and Thompson); National Cancer Institute, Division of Cancer Prevention and Control, Bethesda, Md (Dr Clifford); Department of Radiology, University of Cincinnati (Ohio) (Ms Goldman and Dr Moskowitz); Department of Community Health, Tufts University, Boston, Mass (Drs Gorbach and Woods); and Group Health Cooperative, Seattle (Dr Thompson).
Footnotes
Accepted for publication August 29,1989.
Reprint requests to National Cancer Institute, 9000 Rockville Pike, Executive Plaza North, 212B, Bethesda, MD 20892 (Dr Clifford).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Cancer Prevention: From 1727 to Milestones of the Past 100 Years
Lippman and Hawk
Cancer Res. 2009;69:5269-5284.
ABSTRACT
| FULL TEXT
Low-Fat Dietary Pattern and Risk of Treated Diabetes Mellitus in Postmenopausal Women: The Women's Health Initiative Randomized Controlled Dietary Modification Trial
Tinker et al.
Arch Intern Med 2008;168:1500-1511.
ABSTRACT
| FULL TEXT
Low-Fat Dietary Pattern and Cancer Incidence in the Women's Health Initiative Dietary Modification Randomized Controlled Trial
Prentice et al.
JNCI J Natl Cancer Inst 2007;99:1534-1543.
ABSTRACT
| FULL TEXT
Lifestyle Intervention Development Study to Improve Physical Function in Older Adults With Cancer: Outcomes From Project LEAD
Demark-Wahnefried et al.
JCO 2006;24:3465-3473.
ABSTRACT
| FULL TEXT
Low-Fat Dietary Pattern and Risk of Invasive Breast Cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial
Prentice et al.
JAMA 2006;295:629-642.
ABSTRACT
| FULL TEXT
Low-Fat Dietary Pattern and Risk of Colorectal Cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial
Beresford et al.
JAMA 2006;295:643-654.
ABSTRACT
| FULL TEXT
Dietary Fat Intake and Regulation of Energy Balance: Implications for Obesity
Hill et al.
J. Nutr. 2000;130:284-284.
ABSTRACT
| FULL TEXT
Individually randomized intervention trials for disease prevention and control
Anderson and Prentice
Stat Methods Med Res 1999;8:287-309.
ABSTRACT
Very Low Fat Diets
Lichtenstein and Van Horn
Circulation 1998;98:935-939.
FULL TEXT
Systematic review of dietary intervention trials to lower blood total cholesterol in free-living subjects • Commentary: Dietary change, cholesterol reduction, and the public health---what does meta-analysis add?
Tang et al.
BMJ 1998;316:1213-1220.
ABSTRACT
| FULL TEXT
Cholesterol-Lowering Diets: A Review of the Evidence
Denke
Arch Intern Med 1995;155:17-26.
ABSTRACT
What If Americans Ate Less Fat?
Sheppard and Prentice
JAMA 1992;267:361-362.
ABSTRACT
|
