This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Larry J. Goodman, MD; Gordon M. Trenholme, MD; Raymond L. Kaplan, PhD; John Segreti, MD; David Hines, MD; Russell Petrak, MD; Jeffrey A. Nelson, MD; Kathleen W. Mayer, MT(ASCP); William Landau, PhD; George W. Parkhurst, PhD; Stuart Levin, MD

Arch Intern Med. 1990;150(3):541-546.

Abstract
• From June 1985 to September 1987, 202 adults were enrolled in a randomized, double-blinded study comparing ciprofloxacin (500 mg) with sulfamethoxazole and trimethoprim (160 mg/800 mg) or placebo for adults with acute diarrhea. All patients were treated on the day of presentation and received medication on a twice-daily schedule (every 12 hours) for 5 days. Bacterial isolates from these patients included 35 Campylobacter, 18 Shigella, and 15 Salmonella. Treatment at the time of presentation with ciprofloxacin compared with placebo shortened the duration of diarrhea (2.4 vs 3.4 days), and increased the percentage of patients cured or improved by treatment days 1,3,4, and 5. Similar significant differences for sulfamethoxazole and trimethoprim compared with placebo were not seen.

(Arch Intern Med. 1990;150:541-546)

Author Affiliations
From the Section of Infectious Disease, Department of Medicine (Drs Goodman, Trenholme, Kaplan, Segreti, Nelson, and Levin), Section of Clinical Microbiology, Office of Consolidated Laboratory Services (Drs Kaplan and Landau), Departments of Immunology/Microbiology (Drs Kaplan and Landau, and Ms Mayer), and Pharmocology (Dr Parkhurst), Rush–Presbyterian St Luke's Medical Center, Chicago, Ill; Section of Infectious Disease, Department of Medicine, Grant Hospital, Chicago, Ill (Dr Hines); and Section of Infectious Disease, Department of Medicine, MacNeal Hospital, Berwyn, Ill (Dr Petrak).

Footnotes
Accepted for publication October 31,1989.

Reprint requests to the Section of Infectious Disease, Rush–Presbyterian St Luke's Medical Center, Chicago, IL 60612 (Dr Goodman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Emergence of fluoroquinolone resistance in the native Campylobacter coli population of pigs exposed to enrofloxacin
Delsol et al.
J Antimicrob Chemother 2004;53:872-874.
ABSTRACT | FULL TEXT  

Acute Infectious Diarrhea
Thielman and Guerrant
NEJM 2004;350:38-47.
FULL TEXT  

Acute bacterial gastroenteritis: a study of adult patients with positive stool cultures treated in the emergency department
Chan et al.
Emerg. Med. J. 2003;20:335-338.
ABSTRACT | FULL TEXT  

The Risk of the Hemolytic-Uremic Syndrome after Antibiotic Treatment of Escherichia coli O157:H7 Infections
Wong et al.
NEJM 2000;342:1930-1936.
ABSTRACT | FULL TEXT  

Quinolone-Resistant Campylobacter jejuni Infections in Minnesota, 1992-1998
Smith et al.
NEJM 1999;340:1525-1532.
ABSTRACT | FULL TEXT  

Empiric Treatment of Acute Diarrheal Disease with Norfloxacin: A Randomized, Placebo-Controlled Study
Wistrom et al.
ANN INTERN MED 1992;117:202-208.
ABSTRACT  

A Note of Caution on Empiric Use of Ciprofloxacin for Diarrhea
Manzione
Arch Intern Med 1992;152:213-217.
ABSTRACT  

Treatment of Travelers' Diarrhea: Ciprofloxacin plus Loperamide Compared with Ciprofloxacin Alone: A Placebo-Controlled, Randomized Trial
Taylor et al.
ANN INTERN MED 1991;114:731-734.
ABSTRACT