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Robert J. Lipsy, PharmD; Brian Fennerty, MD; Timothy C. Fagan, MD

Arch Intern Med. 1990;150(4):745-751.

Abstract
• Histamine₂ receptor antagonists are beneficial in treating gastric and duodenal ulcers, gastroesophageal reflux, and hypersecretory states. Histamine₂ receptor antagonists are helpful for the prevention of stress ulceration and recurrence of gastric and duodenal ulcer. Four histamine₂ blockers are approved for clinical use: cimetidine, famotidine, ranitidine, and nizatidine. This review compares these agents in three areas: efficacy, adverse drug reactions, and drug interactions. Although limited published data exist for famotidine and nizatidine, both are as effective as the better-studied ranitidine and cimetidine when administered appropriately. Subtle differences exist among the four agents in the areas of drug interactions and adverse effects. Individual practitioners may decide if these differences are important enough to affect drug choice.

(Arch Intern Med. 1990;150:745-751)

Author Affiliations
From the Department of Pharmacy Practice, College of Pharmacy, University of Arizona (Dr Lipsy), and the Gastroenterology (Dr Fennerty) and General Medicine Sections (Dr Fagan), Department of Medicine, University of Arizona College of Medicine, Tucson.

Footnotes
Accepted for publication August 8,1989.

Reprint requests to College of Pharmacy, University of Arizona, Tucson, AZ 85724 (Dr Lipsy).

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