This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Keith A. Johnson, MD; B. Leonard Holman, MD; T. John Rosen, PhD; J. Steven Nagel, MD; Robert J. English, CNMT; John H. Growdon, MD

Arch Intern Med. 1990;150(4):752-756.

Abstract
• To determine the diagnostic accuracy of iofetamine hydrochloride I 123 (IMP) with single photon emission computed tomography in Alzheimer's disease, we studied 58 patients with AD and 15 age-matched healthy control subjects. We used a qualitative method to assess regional IMP uptake in the entire brain and to rate image data sets as normal or abnormal without knowledge of subjects' clinical classification. The sensitivity and specificity of IMP with single photon emission computed tomography in AD were 88% and 87%, respectively. In 15 patients with mild cognitive deficits (Blessed Dementia Scale score, 10), sensitivity was 80%. With the use of a serniquantitative measure of regional cortical IMP uptake, the parietal lobes were the most functionally impaired in AD and the most strongly associated with the patients' Blessed Dementia Scale scores. These results indicated that IMP with single photon emission computed tomography may be a useful adjunct in the clinical diagnosis of AD in early, mild disease.

(Arch Intern Med. 1990;150:752-756)

Author Affiliations
From the Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston (Drs Johnson, Holman, and Nagel and Mr English); Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston (Drs Johnson, Rosen, and Growdon); and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge (Dr Rosen).

Footnotes
Accepted for publication August 28,1989.

Reprint requests to Department of Radiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (Dr Holman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

CNS Assessment Using Functional Neuro-PET Imaging
Laven and Bednarczyk
Journal of Pharmacy Practice 2001;14:308-331.
ABSTRACT  

Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
Knopman et al.
Neurology 2001;56:1143-1153.
ABSTRACT | FULL TEXT  

SPECT perfusion imaging in the diagnosis of Alzheimer's disease: A clinical-pathologic study
Jagust et al.
Neurology 2001;56:950-956.
ABSTRACT | FULL TEXT  

The Role of Brain Single Photon Emission Computed Tomography in the Diagnosis of Primary Progressive Aphasia
McDaniel et al.
Arch Neurol 1991;48:1257-1260.
ABSTRACT  

Dementia Screening
Murden
ANN INTERN MED 1991;115:657-658.
ABSTRACT  

Positron Emission Tomography
REIMAN and MINTUN
Arch Intern Med 1990;150:729-731.
ABSTRACT