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Proposed Mechanism of the Inflammatory Attacks in Familial Mediterranean Fever
Yaacov Matzner, MD;
Suhail K. Ayesh, MSc;
Drorith Hochner-Celniker, MD;
Zvi Ackerman, MD;
Mina Ferne, PhD
Arch Intern Med. 1990;150(6):1289-1291.
Abstract
• Peritoneal and synovial fluids of patients with familial Mediterranean fever lack a protein that inhibits neutrophil chemotaxis by antagonizing the complement-derived inflammatory mediator C5a. The C5a inhibitor activity was studied with the use of a C5a binding assay where peritoneal fluids were tested for their ability to inhibit recombinant C5a binding to dibutyryl cyclic adenosine monophosphate–induced U937 cells. In contrast to normal peritoneal fluids, those from patients with familial Mediterranean fever contained less than 1% C5a inhibitor activity. Gel filtration and ion exchange chromatography of peritoneal fluids from those patients did not yield any fraction that inhibited C5a binding. We suggest that the serosal tissue of patients with familial Mediterranean fever is devoid of C5a inhibitor activity and that this deficiency may explain in part the local inflammatory episodes characteristic of this disease.
(Arch Intern Med. 1990;150:1289-1291)
Author Affiliations
From the Hematology Unit (Drs Matzner and Ferne and Mr Ayesh) and the Department of Obstetrics and Gynecology (Dr Hochner-Celniker), Hadassah University Hospital Mount Scopus, and the Department of Gastroenterology, Hadassah University Hospital Ein Karem (Dr Ackerman), Jerusalem, Israel.
Footnotes
Accepted for publication December 4,1989.
Presented in part at the annual meeting of the European Society for Clinical Investigation, Athens, Greece, April 19, 1989.
Reprint requests to Hematology Unit, Hadassah University Hospital Mount Scopus, Jerusalem, Israel 91240 (Dr Matzner).
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