 |
|
The Association of Syphilis With Risk of Human Immunodeficiency Virus Infection in Patients Attending Sexually Transmitted Disease Clinics
Thomas C. Quinn, MD, MS;
Robert O. Cannon, MD, MPH;
David Glasser, MD, MPH;
Samuel L. Groseclose, DVM, MPH;
Wayne S. Brathwaite;
Anthony S. Fauci, MD;
Edward W. Hook III, MD
Arch Intern Med. 1990;150(6):1297-1302.
Abstract
• A serologic survey of 4863 patients attending two inner-city sexually transmitted disease clinics was conducted in 1988 1 year after an initial survey to reassess the prevalence and associated risk factors for human immunodeficiency virus (HIV) infection. The HIV seroprevalence rates had not changed significantly (5.2% in 1987, 4.9% in 1988), and remained higher among men (5.6%) than among women (3.6%). The HIV seroprevalence increased steadily with age, to 34 years in women and to 39 years in men. Of patients with a reactive syphilis serologic test result, 24.3% were HIV infected compared with 3.5% of patients with a nonreactive test for syphilis. In multivariate analysis, a reactive serologic test for syphilis was significantly associated with HIV infection in all major risk behavior categories. Among heterosexuals who denied parenteral drug abuse, HIV infection rates were 6.8 and 8.7 times greater for women and men, respectively, who had a reactive serologic test for syphilis. Evidence of heterosexual transmission of HIV was further suggested by a change in HIV seroprevalence in women from 3.0% in 1987 to 3.6% in 1988, a male to female HIV infection ratio of 1.6, and a 3.0% prevalence of infection among patients who denied established risk factors. This was most evident among those younger than 25 years, in whom 72% of infected women and 46.2% of infected men denied high-risk behaviors. These data demonstrate the strong association between syphilis and HIV infection and the importance of heterosexual HIV transmission in patients attending sexually transmitted disease clinics. This study underscores the need for a more comprehensive control program for sexually transmitted diseases, including syphilis and HIV infection.
(Arch Intern Med. 1990;150:1297-1302)
Author Affiliations
From the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Md (Drs Quinn and Fauci); Division of Infectious Diseases, The Johns Hopkins University (Drs Quinn, Cannon, and Hook) and the Baltimore City Health Department (Drs Glasser, Groseclose, and Hook and Mr Brathwaite), Baltimore, Md.
Footnotes
Accepted for publication January 12,1990.
Deceased.
Reprint requests to the Blalock 1111, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21205 (Dr Quinn).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India.
Reynolds et al.
Sex. Transm. Infect. 2006;82:121-126.
ABSTRACT
| FULL TEXT
Human Immunodeficiency Virus Infection in a Rural Community in the United States
Ellerbrock et al.
Am J Epidemiol 2004;160:582-588.
ABSTRACT
| FULL TEXT
Sex Differences in Risk Factors for HIV Seroconversion Among Injection Drug Users: A 10-Year Perspective
Strathdee et al.
Arch Intern Med 2001;161:1281-1288.
ABSTRACT
| FULL TEXT
Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features
Singh and Romanowski
Clin. Microbiol. Rev. 1999;12:187-209.
ABSTRACT
| FULL TEXT
Serologic Response to Treatment of Syphilis in Patients With HIV Infection
Yinnon et al.
Arch Intern Med 1996;156:321-325.
ABSTRACT
Lumbar Puncture for Evaluation of Latent Syphilis in Hospitalized Patients: High Prevalence of Cerebrospinal Fluid Abnormalities Unrelated to Syphilis
Carey et al.
Arch Intern Med 1995;155:1657-1662.
ABSTRACT
Cerebrospinal Fluid Treponemal Antibodies in Untreated Early Syphilis
Marra et al.
Arch Neurol 1995;52:68-72.
ABSTRACT
Maternal-Newborn Human Immunodeficiency Virus Infection in Harlem
Nicholas et al.
Arch Pediatr Adolesc Med 1994;148:813-819.
ABSTRACT
Children With Unrecognized Human Immunodeficiency Virus Infection: An Emergency Department Perspective
Fein et al.
Arch Pediatr Adolesc Med 1993;147:1104-1108.
ABSTRACT
Who Should Be Screened for HIV Infection? A Cost-effectiveness Analysis
McCarthy et al.
Arch Intern Med 1993;153:1107-1116.
ABSTRACT
Neurosyphilis: A Comparative Study of the Effects of Infection With Human Immunodeficiency Virus
Katz et al.
Arch Neurol 1993;50:243-249.
ABSTRACT
Recently Acquired Syphilis in the Elderly Population
Berinstein and DeHertogh
Arch Intern Med 1992;152:330-332.
ABSTRACT
CD4 Lymphocyte Concentrations in Patients With Newly Identified HIV Infection Attending STD Clinics: Potential Impact on Publicly Funded Health Care Resources
Hutchinson et al.
JAMA 1991;266:253-256.
ABSTRACT
Characteristics of, and HIV Infection Among, Women Served by Publicly Funded HIV Counseling and Testing Services--United States, 1989-1990
JAMA 1991;265:2051-2052.
Characteristics of Patients With Syphilis Attending Baltimore STD Clinics: Multiple High-Risk Subgroups and Interactions With Human Immunodeficiency Virus Infection
Hutchinson et al.
Arch Intern Med 1991;151:511-516.
ABSTRACT
|
