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David Martin, MB, MRCP; Bernard Lown, MD

Arch Intern Med. 1990;150(6):1345-1347.

Abstract
• Three cases are reported in which resolution of severe esophagitic dyspepsia followed amiodarone therapy for cardiac arrhythmias. This effect has proved long lasting. The mechanism of amiodarone action may be related to its calcium antagonist or nitratelike properties that reduce lower esophageal sphincter tone. An alternate hypothesis calls attention to structural similarities between amiodarone and the histamine antagonist ranitidine, and suggests a previously unrecognized action of amiodarone on histamine receptors.

(Arch Intern Med. 1990;150:1345-1347)

Author Affiliations
From the Cardiovascular Laboratories, Department of Nutrition, Harvard University School of Public Health, and the Department of Medicine, Brigham and Women's Hospital, Boston, Mass.

Footnotes
Accepted for publication July 31,1989.

Reprint requests to Harvard University School of Public Health, 21 Longwood Ave, Brookline, MA 02146 (Dr Lown).

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