Apolipoproteins A-I and B as Predictors of Angiographically Defined Coronary Artery Disease

doi:10.1001/archinte.1990.00040031629009

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 150 No. 8, August 1990

Online Only
	•	Online First Table of Contents

Original Investigations

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (64)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Apolipoproteins A-I and B as Predictors of Angiographically Defined Coronary Artery Disease

Richard A. Reinhart; Kosasih Gani; Michael R. Arndt; Steven K Broste

Arch Intern Med. 1990;150(8):1629-1633.

Abstract

Apolipoprotein A-I and B concentrations were measured in 502patients undergoing diagnostic cardiac catheterization to assessthe predictive power of apolipoproteins B and A-I to discriminatebetween patients with coronary artery disease and those withnormal coronary arteries as defined by coronary arteriography.The strength of the associations was compared with that of theassociations between traditional risk factors (eg, smoking status,cholesterol levels) and coronary artery disease. The study populationconsisted of 154 women (mean age, 62.9 years) and 348 men (meanage, 59.6 years). The apolipoprotein A-I concentration averaged(± SD) 124 ± 25 mg/dL and the apolipoprotein Bconcentration, 98 ± 24 mg/dL. In all cases, the apolipoproteinmeasures showed a larger univariate difference between the "normal"(no coronary artery disease) group (66 patients) and the groupwith coronary artery disease (436 patients) than did the correspondingstandard lipoprotein measures. The variable with the strongestassociation with coronary artery disease was the ratio of apolipoproteinA-I to apolipoprotein B, followed by apolipoprotein B level.These findings were confirmed using logistic regression, adjustingfor other coronary artery disease risk factors. Fasting statusdid not affect apolipoprotein A-I or B concentrations. We concludethat the use of apolipoprotein A-I and B concentrations givesadditional information to that supplied by lipoprotein measuresto help predict the presence of coronary artery disease. Sincetraditional lipid measures may be changed by a meal, apolipoproteinsA-I and B might be more useful measures when the fasting statusof a patient is in question.

(Arch Intern Med. 1990;150:1629-1633)

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Ezetimibe added to ongoing statin therapy improves LDL-C goal attainment and lipid profile in patients with diabetes or metabolic syndrome
Denke et al.
Diabetes and Vascular Disease Research 2006;3:93-102.
ABSTRACT

Potential health promotion benefits of lipid testing for all patients presenting with chest pain to an emergency department
Elder et al.
Emerg. Med. J. 2006;23:23-26.
ABSTRACT | FULL TEXT

Association of Apolipoprotein E Genotypes with Serum Lipid Profiles in a Healthy Population of Taiwan
Lin et al.
Ann Clin Lab Sci 2004;34:443-448.
ABSTRACT | FULL TEXT

Fractional Esterification Rate of Cholesterol and Ratio of Triglycerides to HDL-Cholesterol Are Powerful Predictors of Positive Findings on Coronary Angiography
Frohlich and Dobiasova
Clin. Chem. 2003;49:1873-1880.
ABSTRACT | FULL TEXT

ACC/AHA 2002 Guideline Update for the Management of Patients With Chronic Stable Angina--Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina)
Gibbons et al.
Circulation 2003;107:149-158.
FULL TEXT

ACC/AHA 2002 guideline update for the management of patients with chronic stable angina--summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina)
Committee Members et al.
J Am Coll Cardiol 2003;41:159-168.
FULL TEXT

References
Circulation 2002;106:3373-3421.
FULL TEXT

Apolipoprotein B and Coronary Artery Disease in Women : A Cross-sectional Study in Women Undergoing Their First Coronary Angiography
Westerveld et al.
Arterioscler. Thromb. Vasc. Bio. 1998;18:1101-1107.
ABSTRACT | FULL TEXT

Apolipoprotein B and AI distributions in the United States, 1988�1991: results of the National Health and Nutrition Examination Survey III (NHANES III)
Bachorik et al.
Clin. Chem. 1997;43:2364-2378.
ABSTRACT | FULL TEXT

Dose-Response Relationships of Serum Lipid Measurements With the Extent of Coronary Stenosis : Strong, Independent, and Comprehensive
Bolibar et al.
Arterioscler. Thromb. Vasc. Bio. 1995;15:1035-1042.
ABSTRACT | FULL TEXT

Apolipoproteins C-II and C-III in Peripheral Arterial Disease
Alessandri et al.
ANGIOLOGY 1994;45:131-136.
ABSTRACT

Gemfibrozil Also Corrects Dyslipidemia in Postmenopausal Women and Smokers
Koskinen et al.
Arch Intern Med 1992;152:90-96.
ABSTRACT

Gender and Lipids in Coronary Artery Disease
Krakauer and Fachnie
Arch Intern Med 1991;151:1881-1881.
ABSTRACT

Gender and Lipids in Coronary Artery Disease-Reply
Reinhart et al.
Arch Intern Med 1991;151:1881-1882.
ABSTRACT

| | |