 |
|
Comparison of Psyllium Hydrophilic Mucilloid and Cellulose as Adjuncts to a Prudent Diet in the Treatment of Mild to Moderate Hypercholesterolemia
Eleanor G. Levin, MD;
Valery T. Miller, MD;
Richard A. Muesing, PhD;
Diane B. Stoy, RN, MA;
Timothy K. Balm;
John C. LaRosa, MD
Arch Intern Med. 1990;150(9):1822-1827.
Abstract
• The effects of the administration of 5.1 g of psyllium or placebo (cellulose) twice daily for 16 weeks were compared as adjuncts to a prudent diet in the management of moderate hypercholesterolemia in a parallel, double-blind study. Psyllium decreased the total cholesterol level by 5.6% and the low-density lipoprotein cholesterol level by 8.6%, whereas the levels were unchanged in the placebo group. The high-density lipoprotein cholesterol level decreased during the diet stabilization period in both groups and returned to near-baseline values by week 16. Plasma triglyceride levels did not change substantially in either group. Subject compliance to treatment was greater than 95%. These data suggest that psyllium hydrophilic mucilloid in a twice-daily regimen may be a useful and safe adjunct to a prudent diet in the treatment of moderate hypercholesterolemia.
(Arch Intern Med. 1990;150:1822-1827)
Author Affiliations
From the Lipid Research Clinic, The George Washington Medical Center, Washington, DC (Drs Levin, Miller, Muesing, and LaRosa and Ms Stoy), and The Procter & Gamble Company, Cincinnati, Ohio (Mr Balm). Dr Levin is now with the Division of Cardiology, Kaiser Permanente Medical Group, Santa Clara, Calif.
Footnotes
Accepted for publication May 3,1990.
Reprint requests to The George Washington University Medical Center, 901 23rd St NW, Washington, DC 20037 (Dr LaRosa).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia
Anderson et al.
Am J Clin Nutr 2000;71:1433-1438.
ABSTRACT
| FULL TEXT
Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials1
Anderson et al.
Am J Clin Nutr 2000;71:472-479.
ABSTRACT
| FULL TEXT
Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia
Anderson et al.
Am J Clin Nutr 1999;70:466-473.
ABSTRACT
| FULL TEXT
Cholesterol-lowering effects of dietary fiber: a meta-analysis
Brown et al.
Am J Clin Nutr 1999;69:30-42.
ABSTRACT
| FULL TEXT
Native and Partially Hydrolyzed Psyllium Have Comparable Effects on Cholesterol Metabolism in Rats
Arjmandi et al.
J. Nutr. 1997;127:463-469.
ABSTRACT
| FULL TEXT
Patient-Directed, Nonprescription Approaches to Cardiovascular Disease
Simon
Arch Intern Med 1994;154:2283-2296.
ABSTRACT
Hypocholesterolemic Effects of Different Bulk-Forming Hydrophilic Fibers as Adjuncts to Dietary Therapy in Mild to Moderate Hypercholesterolemia
Anderson et al.
Arch Intern Med 1991;151:1597-1602.
ABSTRACT
Anaphylaxis Following Ingestion of a Psyllium-Containing Cereal
Lantner et al.
JAMA 1990;264:2534-2536.
ABSTRACT
|
