 |
|
Effect of Race on Expression of Acquired Immunodeficiency Syndrome-Associated Nephropathy
E. Scott Cantor, MD;
Paul L. Kimmel, MD;
Juan P. Bosch, MD
Arch Intern Med. 1991;151(1):125-128.
Abstract
The prevalence of renal disease associated with the ac quired immunodeficiency syndrome (AIDS) is unknown, but ap pears to vary in different regions. Centers in New York, NY, and Miami, Fla, have reported patients with renal disease complicat ing AIDS. These populations have included large proportions of black patients and intravenous drug abusers. Reports from San Francisco, Calif, have suggested the prevalence of renal disease complicating AIDS is low, but the population was composed primarily of white patients, with a low proportion of drug abusers. The George Washington University Medical Center was the site of treatment for 31.4% of the patients with AIDS in Washington, DC. This population was split roughly evenly between black and white patients. A retrospective survey of patients with both AIDS and renal disease revealed approximately two thirds of the pa tients were black, reflecting the demographics of the population with AIDS; 11% of patients had intravenous drug abuse as a risk factor for the development of AIDS; and 74% had acute renal failure. Of these patients, approximately equal proportions were black and white. Twenty-six percent of the population had chron ic renal failure, but the overwhelming proportion were black. There were no differences between proportions of patients in age, sex, race, or risk factors in patients with acute renal failure and chronic renal failure, but there was a significant difference in the proportions of black and white patients with chronic renal failure. The reason for these differences is unknown, but differ ences in host responses to viral proteins, physiologic adapta tions, or socioeconomic factors in these populations may play an important role in mediating the expression of renal disease in individual patients.
(Arch Intern Med. 1991;151:125-128)
Author Affiliations
From the Renal Division, Department of Medicine, George Washington University Medical Center, Washington, DC.
Footnotes
Accepted for publication July 30, 1990.
Reprint requests to the Department of Medicine, George Washington Uni versity Medical Center, 2150 Pennsylvania Ave NW, Washington, DC 20037 (Dr Kimmel).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
HIV and the Kidney: A Spotlight on Racial Disparities
Wyatt
The Journal of Infectious Disease 2008;197:1490-1492.
FULL TEXT
HIV-associated renal diseases in Africa a desperate need for additional study
Cohen and Kimmel
Nephrol Dial Transplant 2007;22:2116-2119.
FULL TEXT
HIV-1 and HIV-Associated Nephropathy 25 Years Later
Wyatt and Klotman
CJASN 2007;2:S20-S24.
ABSTRACT
| FULL TEXT
Genetic Susceptibility, HIV Infection, and the Kidney
Kiryluk et al.
CJASN 2007;2:S25-S35.
ABSTRACT
| FULL TEXT
Guidelines for the Management of Chronic Kidney Disease in HIV-Infected Patients: Recommendations of the HIV Medicine Association of the Infectious Diseases Society of America
Gupta et al.
Clinical Infectious Diseases 2005;40:1559-1585.
FULL TEXT
Variants in the Wilms' tumor gene are associated with focal segmental glomerulosclerosis in the African American population
Orloff et al.
Physiol. Genomics 2005;21:212-221.
ABSTRACT
| FULL TEXT
Podocan, a Novel Small Leucine-rich Repeat Protein Expressed in the Sclerotic Glomerular Lesion of Experimental HIV-associated Nephropathy
Ross et al.
J. Biol. Chem. 2003;278:33248-33255.
ABSTRACT
| FULL TEXT
Recent Progress in HIV-Associated Nephropathy
Ross and Klotman
J. Am. Soc. Nephrol. 2002;13:2997-3004.
FULL TEXT
Renal Diseases Associated with Human Immunodeficiency Virus Infection: Epidemiology, Clinical Course, and Management
Mayer and Szczech
Clinical Infectious Diseases 2001;33:115-119.
ABSTRACT
| FULL TEXT
Chemokine Receptor CCR5 and CXCR4 Expression in HIV-Associated Kidney Disease
EITNER et al.
J. Am. Soc. Nephrol. 2000;11:856-867.
ABSTRACT
| FULL TEXT
|
