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A Literature Review

Gary Glazer, MD

Arch Intern Med. 1991;151(10):1925-1933.

Abstract
This article reviews the current body of literature linking anabolic steroids to atherogenic alterations in serum lipid levels. Anabolic steroids cause marked high-density lipoprotein level depression (weighted average, 52%) and severe depression of high-density lipoproteinb levels (weighted average, 78%) while raising low-density lipoprotein levels an average of 36%. The mechanism of these lipid changes, their time course in relation to anabolic steroid use, and their dependency on route of anabolic steroid administration are discussed. Interpretation of the observed lipid level changes in light of the epidemiologic data linking lipids to coronary heart disease risk is used to estimate the lipid-based increase in coronary heart disease risk due to anabolic steroid use.

(Arch Intern Med. 1991;151:1925-1933)

Author Affiliations
From Highland Hospital, Rochester, NY.

Footnotes
Accepted for publication March 29, 1991.

Reprint requests to Highland Hospital, 1000 South Ave, Rochester, NY 14620 (Dr Glazer).

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