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Carolyn S. Connelly, MD; Richard S. Panush, MD

Arch Intern Med. 1991;151(10):1963-1966.

Abstract
Purpose.—
To determine if perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) might be associated with increased postoperative morbidity.

Patients and Methods.—
Records from 165 patients undergoing total hip arthroplasty from 1984 to 1987 were reviewed. Patients taking NSAIDs at hospital admission were compared with those who were not.

Results.—
Patients taking NSAIDs had more postoperative bleeding complications (gastrointestinal tract bleeding and/or hypotension) than did patients not taking those agents. Complications were more frequent in patients using NSAIDs with half-lives longer than 6 hours.

Conclusion.—
Patients undergoing elective surgery should stop taking NSAIDs in time to allow elimination of the drug; those patients who need to take these agents perioperatively should use drugs with short half-lives.

(Arch Intern Med. 1991;151:1963-1966)

Author Affiliations
From the Division of Clinical Immunology, Rheumatology, and Allergy, Department of Medicine, College of Medicine, University of Florida and Veterans Affairs Medical Center, Gainesville (Dr Connelly); Department of Medicine, St Barnabas Medical Center, Livingston, NJ, and Department of Medicine, University of Medicine and Dentistry-New Jersey Medical School, Newark (Dr Panush). Dr Connelly is now in private practice in Tampa, Fla.

Footnotes
Accepted for publication March 29, 1991.

Read in part at the Annual Scientific Meeting of the American Rheumatism Association, Houston, Tex, May 26, 1988.

Reprint requests to St Barnabas Medical Center, Livingston, NJ 07039 (Dr Panush).

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