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Steven T. Harris, MD; Harry K. Genant, MD; David J. Baylink, MD; J. Christopher Gallagher, MD; Sherry Katz Karp, MPH; Maureen A. McConnell, MS; Elizabeth M. Green; Ralph W. Stoll, MD

Arch Intern Med. 1991;151(10):1980-1984.

Abstract
The effects of cyclical treatment with estrone sulfate (0.3, 0.625, or 1.25 mg), plus calcium carbonate, on spinal trabecular bone density were compared with placebo in 120 postmenopausal women in this 2-year, multicenter, doubleblind study. While the placebo and 0.3-mg treatment groups lost bone density (-3.6% and -5.1%), the 0.625- and 1.25-mg treatment groups experienced no significant change from baseline at 24 months (-0.8% and +0.7%). The 1.25-mg treatment group was significantly different from the placebo group at 12,18, and 24 months. Although the 0.625-mg treatment group was significantly different from the placebo group only at 18 months, the data suggest that 0.625 and 1.25 mg of estrone sulfate had different effects than placebo and 0.3 mg of estrone sulfate and, given with supplemental calcium, are effective doses for the prevention of spinal bone loss.

(Arch Intern Med. 1991;151:1980-1984)

Author Affiliations
From the Departments of Medicine and Radiology (Drs Harris and Genant), University of California at San Francisco; Jerry L. Pettis Memorial Veterans Hospital Research Service, Loma Linda, Calif (Dr Baylink); Creighton University Medical Center, Omaha, Neb (Dr Gallagher); and the Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Ill (Mss Karp, McConnell, and Green and Dr Stoll).

Footnotes
Accepted for publication March 29, 1991.

Reprint requests to Department of Radiology, University of California, San Francisco, CA 94143 (Dr Harris).

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