This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Daniel M. Lane, MD, PhD; Walter J. McConathy, PhD; Philip C. Comp, MD, PhD; Ronald O. Gilcher, MD

Arch Intern Med. 1991;151(4):800-804.

Abstract
A 3-year-old boy with minor bleeding problems had no plasma fibrinogen measured by both clottable assay and immunoprecipitation. Low normal fibrinogen levels were present in the mother and father. Markedly decreased plasma cholesterol and apolipoprotein B levels were found in the father, proband's brother, and the paternal side of the kindred. The proband and his mother had normal plasma total cholesterol and apolipoprotein B levels. These findings are compatible with autosomal dominant transmission of hypobetalipoproteinemia and autosomal recessive transmission of afibrinogenemia. Two members of the father's family had plasma cholesterol levels below the fifth percentile but elevated levels of fibrinogen (6.0 and 4.4 g/L). Both have symptomatic coronary heart disease. Finding coronary heart disease with very low cholesterol but elevated fibrinogen levels is consistent with fibrinogen levels being an independent risk factor for coronary heart disease.

(Arch Intern Med. 1991;151:800-804)

Author Affiliations
From the Lipoprotein and Atherosclerosis Research Program (Drs Lane and McConathy), Cardiovascular Biology Research Program (Dr Comp), Oklahoma Medical Research Foundation, and Oklahoma Blood Institute (Dr Gilcher), Oklahoma City.

Footnotes
Accepted for publication January 12, 1990.

Reprint requests to Lipoprotein/Atherosclerosis Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104 (Dr Lane).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?