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Philippe Giral, MD; Isabelle Pithois-Merli, MD; Vincenzo Filitti, MD; Jaime Levenson, MD; Marie Christine Plainfosse, MD; Christine Mainardi, MD; Alain C. Simon, MD

Arch Intern Med. 1991;151(5):950-956.

Abstract
Ultrasonic detection of atherosclerotic plaque of carotid abdominal aortic and femoral arteries and evaluation of risk factors were performed in 208 hypercholesterolemic men without cardiovascular disease. Twenty-six percent of them had no plaque. Plaque at the carotid, aortic, and femoral sites was found in 37%, 48%, and 53% of subjects, respectively. Plaque was associated (1) in carotid arteries with increased total and low-density lipoprotein cholesterol; (2) in the aorta with increased age, pressure, glycemia, and smoking; and (3) in femoral arteries with increased age, systolic pressure, low-density lipoprotein cholesterol, and smoking. Multiple regression analysis showed correlations between carotid plaque and low-density lipoprotein cholesterol; aortic plaque and age, smoking, glycemia, and pressure; femoral plaque and age, smoking, and pressure. This suggests that multiple risk factors influence lesions, and risk profile differs according to atherosis site.

(Arch Intern Med. 1991;151:950-956)

Author Affiliations
Prévention Cardio-vasculaire en Médecine du Travail METRA Group

From the Cardiovascular Preventive Medicine Center and National Institute of Health and Medical Research (INSERM) U 28 (Drs Giral, Pithois-Merli, Filitti, Levenson, and Simon) and Department of Radiology (Drs Plainfosse and Mainardi), Broussais Hospital, Paris.

Footnotes
Accepted for publication October 16, 1990.

Reprint requests to Centre de Diagnostic, Hôpital Broussais, 96 Rue Didot, 75674 Paris Cedex 14, France (Dr Simon).

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