Can Vitamin D Deficiency Produce an Unusual Pain Syndrome?

doi:10.1001/archinte.1991.00400080144029

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Vol. 151 No. 8, AUGUST 1991

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Can Vitamin D Deficiency Produce an Unusual Pain Syndrome?

F. Michael Gloth III, MD; Jennifer M. Lindsay, PA-C; Lorrie B. Zelesnick, PA-C; William B. Greenough III, MD

Arch Intern Med. 1991;151(8):1662-1664.

Abstract

An unusual pain occurred in five patients in the presence ofcompromised vitamin D status and resolved 5 to 7 days aftersupplementation with vitamin D in the form of ergocalciferol.The pain had a hyperesthetic quality and did not respond tothe use of analgesics, including opiate derivatives. Treatmentwith therapeutic levels of a tricyclic antidepressant did notbring relief of symptoms. In one case, months after treatmentand subsequent improvement of vitamin D status and pain, thevitamin D status again declined and the pain recurred. The painagain resolved with vitamin D replacement and improvement oflevels. There may be a pain syndrome associated with vitaminD depletion that appears as hyperesthesia worsened by light,superficial pressure or even small increments of movement. Thispain restricts mobility and function and may lead to furthercomplications, such as pressure sores.

(Arch Intern Med. 1991;151:1662-1664)

Author Affiliations

From the Division of Geriatric Medicine and Gerontology, Department of Medicine, The Johns Hopkins University School of Medicine (Drs Gloth and Greenough) and The Francis Scott Key Medical Center (Drs Gloth and Greenough and Mss Lindsay and Zelesnick), Baltimore, Md.

Footnotes

Accepted for publication November 21, 1990.

Reprint requests to Gerontology Research Center/Applied PhysiologySection, 4940 Eastern Ave, Baltimore, MD 21224 (Dr Gloth).

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