Refractory Potassium Repletion: A Consequence of Magnesium Deficiency

doi:10.1001/archinte.1992.00400130066006

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 152 No. 1, JANUARY 1992

Online Only
	•	Online First Table of Contents

REVIEW ARTICLES

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (65)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Refractory Potassium Repletion

A Consequence of Magnesium Deficiency

Robert Whang, MD; David D. Whang, MD; Michael P. Ryan, PhD

Arch Intern Med. 1992;152(1):40-45.

Abstract

Experimental and clinical observations support the view thatuncorrected magnesium (Mg) deficiency impairs repletion of cellularpotassium (K). This is consistent with the observed close associationbetween K and Mg depletion. Concomitant Mg deficiency in K-depletedpatients ranges from 38% to 42%. Refractory K repletion dueto unrecognized concurrent Mg deficiency can be clinically perplexing.Refractory K repletion as a consequence of Mg deficiency maybe operative in patients with congestive failure, digitalistoxicity, cisplatin therapy, and in patients receiving potentloop diuretics. Therefore, we recommend that: (1) serum Mg beroutinely assessed in any patients in whom serum electrolytesare necessary for clinical management and (2) until serum Mgis routinely performed consideration should be given to treatinghypokalemic patients with both Mg as well as K to avoid theproblem of refractory K repletion due to coexisting Mg deficiency.

(Arch Intern Med. 1992;152:40-45)

Author Affiliations

From the Department of Medicine, University of Oklahoma and Veterans Administration Medical Center, Oklahoma City (Dr R. Whang); Department of Medicine, Indiana University, Indianapolis (Dr D. Whang); and Department of Pharmacology, University College, Dublin, Ireland (Dr Ryan).

Footnotes

Accepted for publication July 22, 1991.

Reprint requests to the Veterans Affairs Outpatient Clinic,300 Ala Moana Blvd, Honolulu, HI 96850 (Dr R. Whang).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Dyselectrolytemia in acute kidney injury causing tetany and quadriparesis
Palkar et al.
BMJ Case Reports 2011;2011:bcr0620114332-bcr0620114332.
ABSTRACT | FULL TEXT

Comparison of reflective and reflex testing for hypomagnesaemia in severe hypokalaemia
Jones and Twomey
J. Clin. Pathol. 2009;62:816-819.
ABSTRACT | FULL TEXT

Best practice in primary care pathology: review 9
Smellie et al.
J. Clin. Pathol. 2007;60:966-974.
ABSTRACT | FULL TEXT

Guidelines for management of patients with a short bowel.
Nightingale et al.
Gut 2006;55:iv1-iv12.
FULL TEXT

Serum magnesium must also be known in profound hypokalaemia
Loughrey
BMJ 2002;324:1039-1039.
FULL TEXT

Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H+-K+-ATPase deficiency
Simpson and Schwartz
Arch. Dis. Child. 2001;84:504-507.
ABSTRACT | FULL TEXT

New Guidelines for Potassium Replacement in Clinical Practice: A Contemporary Review by the National Council on Potassium in Clinical Practice
Cohn et al.
Arch Intern Med 2000;160:2429-2436.
ABSTRACT | FULL TEXT

Hypomagnesemia
AGUS
J. Am. Soc. Nephrol. 1999;10:1616-1622.
FULL TEXT

Emergency management of meningococcal disease
Pollard et al.
Arch. Dis. Child. 1999;80:290-296.
FULL TEXT

Refractory Potassium Repletion due to Magnesium Deficiency
Matz
Arch Intern Med 1992;152:2346-2346.
ABSTRACT

Vitamin and Mineral Supplementation in Patients with Diabetes Mellitus
Baker and Campbell
The Diabetes Educator 1992;18:420-427.

| | |