Objective.
To determine the relative proportions of the diagnostic categories in patients with fever of unknown origin who were examined in the 1980s.
Study Design.
Prospective case series.
Setting.
General Internal Medicine Service based at University Hospital, Leuven, Belgium.
Patients. —
One hundred ninety-nine consecutive patients meeting the classic criteria of fever of unknown origin who were treated in the 1980s
Main Outcome Measurement.
The final diagnosis es tablished at discharge or during follow-up.
Results.
Infections were found in 45 patients (22.6%), tumors were found in 14 (7%), multisystem diseases were found in 42 (21.5%), drug-related fever was found in six (3%), factitious fever was found in seven (3.5%), habitual hyperthermia was found in five (2.5%), miscellaneous dis eases were found in 29 (14.5%), and no diagnosis was reached in 51 (25.6%).
Conclusions.
Tumors were a less important cause of fe ver of unknown origin in the 1980s. The same holds true for some infectious diseases, such as abscesses and hepatobil iary disorders. Multisystem diseases were more frequently found, and the number of undiagnosed cases increased. Al though these shifts in the disease spectrum in fever of un known origin most probably resulted from a constellation of factors, we suspect that these changes are mainly due to easy and early diagnosis by new diagnostic modalities, such as ultrasonography and computed tomography, of previ ously common causes of fever of unknown origin.
(Arch Intern Med. 1992;152:51-55)
7.2.2 Fever of unknown origin
Vanderschueren and Knockaert
OTM 2011;5:med-9780199204854-chapter-med-9780199204854-chapter.
ABSTRACT
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Meller et al.
JNM 2007;48:35-45.
ABSTRACT
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Knockaert et al.
Arch Intern Med 2003;163:1976-1977.
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From Prolonged Febrile Illness to Fever of Unknown Origin: The Challenge Continues
Vanderschueren et al.
Arch Intern Med 2003;163:1033-1041.
ABSTRACT
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A Comprehensive Evidence-Based Approach to Fever of Unknown Origin
Mourad et al.
Arch Intern Med 2003;163:545-551.
ABSTRACT
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Mueller et al.
Arch Intern Med 2002;162:1305-1309.
ABSTRACT
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Kjaer and Lebech
JNM 2002;43:140-144.
ABSTRACT
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Fever of unknown origin
Anuradha et al.
Postgrad. Med. J. 1999;75:495-497.
FULL TEXT
Users' Guides to the Medical Literature: XV. How to Use an Article About Disease Probability for Differential Diagnosis
Richardson et al.
JAMA 1999;281:1214-1219.
FULL TEXT
Long-term Follow-up of Patients With Undiagnosed Fever of Unknown Origin
Knockaert et al.
Arch Intern Med 1996;156:618-620.
ABSTRACT
Acute Fevers of Unknown Origin: A Plea for Restraint
DiNubile
Arch Intern Med 1993;153:2525-2526.
ABSTRACT
ANOTHER LOOK AT FEVER OF UNKNOWN ORIGIN
JWatch General 1992;1992:5-5.
FULL TEXT
