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  Vol. 152 No. 1, JANUARY 1992 TABLE OF CONTENTS
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Serum Cholesterol, Blood Pressure, Cigarette Smoking, and Death From Coronary Heart Disease Overall Findings and Differences by Age for 316099 White Men

James D. Neaton, PhD; Deborah Wentworth, MPH

Arch Intern Med. 1992;152(1):56-64.


Abstract

To assess the combined influence of blood pressure (BP), serum cholesterol level, and cigarette smoking on death from coronary heart disease (CHD) and to describe how these associations vary with age, data on those factors and on mortality for 316 099 men screened for the Multiple Risk Factor Intervention Trial (MRFIT) were examined. Vital sta tus of participants has been determined after an average follow-up of 12 years; 6327 deaths from CHD have been identified. Strong graded relationships between serum cho lesterol levels above 4.65 mmol/L (180 mg/dL), systolic BP above 110 mm Hg, and diastolic BP above 70 mm Hg and mortality due to CHD were evident. Smokers with serum cholesterol and systolic BP levels in the highest quintiles had CHD death rates that were approximately 20 times greater than nonsmoking men with systolic BP and cholesterol lev els in the lowest quintile. Systolic and diastolic BP, serum cholesterol level, and cigarettes per day were significant predictors of death due to CHD in all age groups. Systolic BP was a stronger predictor than diastolic BP. These results, together with the findings of clinical trials, offer strong support for intensified preventive efforts in all age groups.

(Arch Intern Med. 1992;152:56-64)



Author Affiliations

for the Multiple Risk Factor Intervention Trial Research Group

From the Division of Biostatistics, School of Public Health, Uni versity of Minnesota, Minneapolis.


Footnotes

Accepted for publication August 6, 1991.

Reprint requests to Division of Biostatistics, School of Public Health, University of Minnesota, 2221 University Ave SE, Suite 200, Minneapolis, MN 55414 (Dr Neaton).



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FULL TEXT  

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References
Circulation 2002;106:3373-3421.
FULL TEXT  

The Underlying Risk of Death After Myocardial Infarction in the Absence of Treatment
Law et al.
Arch Intern Med 2002;162:2405-2410.
ABSTRACT | FULL TEXT  

Treatment and Control of Hypertension in the Community: A Prospective Analysis
Lloyd-Jones et al.
Hypertension 2002;40:640-646.
ABSTRACT | FULL TEXT  

Cardiovascular Disease Risk Factors Are Related to Adult Adiposity but Not Birth Weight in Young Guatemalan Adults
Stein et al.
J. Nutr. 2002;132:2208-2214.
ABSTRACT | FULL TEXT  

Risk factor thresholds: their existence under scrutiny
Law and Wald
BMJ 2002;324:1570-1576.
FULL TEXT  

Antecedent hypertension and heart failure after myocardial infarction
Richards et al.
J Am Coll Cardiol 2002;39:1182-1188.
ABSTRACT | FULL TEXT  

Definition of new targets in cardiovascular prevention from young into old age
Staessen
Eur Heart J 2002;23:507-509.
FULL TEXT  

Combined effects of systolic blood pressure and serum cholesterol on cardiovascular mortality in young (<55 years) men and women
Thomas et al.
Eur Heart J 2002;23:528-535.
ABSTRACT | FULL TEXT  

The Changing Face of Hypertension: Is Systolic Blood Pressure the Final Answer?
Deedwania
Arch Intern Med 2002;162:506-508.
FULL TEXT  

Relation of Cigarette Smoking to 25-Year Mortality in Middle-aged Men with Low Baseline Serum Cholesterol : The Chicago Heart Association Detection Project in Industry
Blanco-Cedres et al.
Am J Epidemiol 2002;155:354-360.
ABSTRACT | FULL TEXT  

Office Blood Pressures, Arterial Compliance Characteristics, and Estimated Cardiac Load
Izzo et al.
Hypertension 2001;38:1467-1470.
ABSTRACT | FULL TEXT  

Impact of High-Normal Blood Pressure on the Risk of Cardiovascular Disease
Vasan et al.
NEJM 2001;345:1291-1297.
ABSTRACT | FULL TEXT  

One-Year Study of Felodipine or Placebo for Stage 1 Isolated Systolic Hypertension
Black et al.
Hypertension 2001;38:1118-1123.
ABSTRACT | FULL TEXT  

Risk factors and incident coronary heart disease in Chinese, Malay and Asian Indian males: the Singapore Cardiovascular Cohort Study
Lee et al.
Int J Epidemiol 2001;30:983-988.
ABSTRACT | FULL TEXT  

DASH (Dietary Approaches to Stop Hypertension) Diet Is Effective Treatment for Stage 1 Isolated Systolic Hypertension
Moore et al.
Hypertension 2001;38:155-158.
ABSTRACT | FULL TEXT  

Pulse Pressure Compared With Other Blood Pressure Indexes in the Prediction of 25-Year Cardiovascular and All-Cause Mortality Rates: The Chicago Heart Association Detection Project in Industry Study
Miura et al.
Hypertension 2001;38:232-237.
ABSTRACT | FULL TEXT  

Cardiovascular Mortality in Hypertensive Men According to Presence of Associated Risk Factors
Thomas et al.
Hypertension 2001;37:1256-1261.
ABSTRACT | FULL TEXT  

Evidence based management of hypertension: Cardiovascular risk factors and their effects on the decision to treat hypertension: evidence based review
Padwal et al.
BMJ 2001;322:977-980.
FULL TEXT  

Moderate dietary fat consumption as a risk factor for ischemic heart disease in a population with a low fat intake: a case-control study in Korean men
Suh et al.
Am. J. Clin. Nutr. 2001;73:722-727.
ABSTRACT | FULL TEXT  

Coffee Consumption and Serum Lipids: A Meta-Analysis of Randomized Controlled Clinical Trials
Jee et al.
Am J Epidemiol 2001;153:353-362.
ABSTRACT | FULL TEXT  

Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk)
Khaw et al.
BMJ 2001;322:15-15.
ABSTRACT | FULL TEXT  

Should diastolic and systolic blood pressure be considered for cardiovascular risk evaluation: a study in middle-aged men and women
Benetos et al.
J Am Coll Cardiol 2001;37:163-168.
ABSTRACT | FULL TEXT  

Microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities in a large non-diabetic population. The PREVEND (Prevention of REnal and Vascular ENdstage Disease) study
Diercks et al.
Eur Heart J 2000;21:1922-1927.
ABSTRACT  

Statin therapy, lipid levels, C-reactive protein and the survival of patients with angiographically severe coronary artery disease
Horne et al.
J Am Coll Cardiol 2000;36:1774-1780.
ABSTRACT | FULL TEXT  

Dietary fat and adult diseases and the implications for childhood nutrition: an epidemiologic approach
Law
Am. J. Clin. Nutr. 2000;72 :1291S-1296S.
ABSTRACT | FULL TEXT  

Pulse Pressure and Mortality in Older People
Glynn et al.
Arch Intern Med 2000;160:2765-2772.
ABSTRACT | FULL TEXT  

Identifying patients at risk for coronary heart disease: implications from trials of lipid-lowering drug therapy
Isles and Paterson
QJM 2000;93:567-574.
ABSTRACT | FULL TEXT  

High Triglycerides and Low HDL Cholesterol and Blood Pressure and Risk of Ischemic Heart Disease
Jeppesen et al.
Hypertension 2000;36:226-232.
ABSTRACT | FULL TEXT  

Electron-beam computed tomography for detection of early signs of coronary arteriosclerosis
Erbel et al.
Eur Heart J 2000;21:720-732.
 

Importance of Systolic Blood Pressure in Older Americans
Izzo et al.
Hypertension 2000;35:1021-1024.
FULL TEXT  

Pulse Pressure Not Mean Pressure Determines Cardiovascular Risk in Older Hypertensive Patients
Blacher et al.
Arch Intern Med 2000;160:1085-1089.
ABSTRACT | FULL TEXT  

Electron beam computed tomography: on its way into mainstrem cardiology?
Sechtem
Eur Heart J 2000;21:87-91.
 

Reliability of Self-reported Blood Pressure Measurements
Johnson et al.
Arch Intern Med 1999;159:2689-2693.
ABSTRACT | FULL TEXT  

Smoking and Atherosclerotic Cardiovascular Disease in Men With Low Levels of Serum Cholesterol: The Korea Medical Insurance Corporation Study
Jee et al.
JAMA 1999;282:2149-2155.
ABSTRACT | FULL TEXT  

Coronary Heart Disease: Reducing the Risk : The Scientific Background to Primary and Secondary Prevention of Coronary Heart DiseaseA Worldwide View
Assmann et al.
Arterioscler. Thromb. Vasc. Bio. 1999;19:1819-1824.
FULL TEXT  

Which Blood Pressure Measurement Is More Important in the Elderly?
Elliott
Arch Intern Med 1999;159:1165-1166.
FULL TEXT  

Sex, Age, Cardiovascular Risk Factors, and Coronary Heart Disease : A Prospective Follow-Up Study of 14 786 Middle-Aged Men and Women in Finland
Jousilahti et al.
Circulation 1999;99:1165-1172.
ABSTRACT | FULL TEXT  

Maximizing the Cost-effectiveness of Lipid-Lowering Therapy
Jacobson et al.
Arch Intern Med 1998;158:1977-1989.
ABSTRACT | FULL TEXT  

Beyond CONSORT: Need for Improved Reporting Standards for Clinical Trials
Meinert
JAMA 1998;279:1487-1489.
FULL TEXT  

Homocysteine and Ischemic Heart Disease: Results of a Prospective Study With Implications Regarding Prevention
Wald et al.
Arch Intern Med 1998;158:862-867.
ABSTRACT | FULL TEXT  

Serum Cholesterol Distribution and Coronary Heart Disease Risk : Observations and Predictions Among Middle-aged Population in Eastern Finland
Jousilahti et al.
Circulation 1998;97:1087-1094.
ABSTRACT | FULL TEXT  

The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Arch Intern Med 1997;157:2413-2446.
ABSTRACT  

Antecedent Hypertension Confers Increased Risk for Adverse Outcomes After Initial Myocardial Infarction
Haider et al.
Hypertension 1997;30:1020-1024.
ABSTRACT | FULL TEXT  

Diastolic Pressure Underestimates Age-Related Hemodynamic Impairment
Galarza et al.
Hypertension 1997;30:809-816.
ABSTRACT | FULL TEXT  

The Multiple Risk Factor Intervention Trial (MRFIT) A Return to a Landmark Trial
Gotto
JAMA 1997;277:595-597.
ABSTRACT  

A New Classification Scheme for Hypertension Based on Relative and Absolute Risk With Implications for Treatment and Reimbursement
Black and Yi
Hypertension 1996;28:719-724.
ABSTRACT | FULL TEXT  

The Role of Hypertension in the Pathogenesis of Heart Failure: A Clinical Mechanistic Overview
Vasan and Levy
Arch Intern Med 1996;156:1789-1796.
ABSTRACT  

Mortality After 16 Years for Participants Randomized to the Multiple Risk Factor Intervention Trial
Circulation 1996;94:946-951.
ABSTRACT | FULL TEXT  

Coronary Heart Disease Risk Factors in Men and Women Aged 60 Years and Older : Findings From the Systolic Hypertension in the Elderly Program
Frost et al.
Circulation 1996;94:26-34.
ABSTRACT | FULL TEXT  

Body Weight, Cardiovascular Risk Factors, and Coronary Mortality : 15-Year Follow-up of Middle-aged Men and Women in Eastern Finland
Jousilahti et al.
Circulation 1996;93:1372-1379.
ABSTRACT | FULL TEXT  

North of England evidence based guidelines development project: summary version of evidence based guideline for the primary care management of stable angina
North of England Stable Angina Guideline Developme
BMJ 1996;312:827-832.
FULL TEXT  

Blood Pressure and End-Stage Renal Disease in Men
Klag et al.
NEJM 1996;334:13-18.
ABSTRACT | FULL TEXT  

Effects of Regular Exercise on Blood Pressure and Left Ventricular Hypertrophy in African-American Men with Severe Hypertension
Kokkinos et al.
NEJM 1995;333:1462-1467.
ABSTRACT | FULL TEXT  





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