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MAJ Daniel R. Ouellette, MC, USA; MAJ J. William Kelly, MC; MAJ Gregg T. Anders, MC

Arch Intern Med. 1992;152(2):321-324.

Abstract
Background.—
Serum angiotensin-converting enzyme (ACE) level is elevated in a number of disease states and medical conditions. Based on review of the medical literature, we postulated that serum ACE level elevation may occur during infection with the human immunodeficiency virus (HIV).

Methods.—
In a prospective, controlled study, serum ACE levels of HIV-positive patients were compared with those of an HIV-negative control population.

Results. —
Serum ACE levels were significantly elevated in patients with the acquired immunodeficiency syndrome (55.4± 11.4 U/L) and in patients with an intermediate stage of HIV infection (57.2±25.3 U/L) when compared with levels in controls (31.9±14.0 U/L).

Conclusions. —
Elevated serum ACE levels occur in HIV infection and may be an important marker for this disease.

(Arch Intern Med. 1992;152:321-324)

Author Affiliations
USA; USA

From the Department of Pulmonary/Critical Care Medicine, Fitzsimons Army Medical Center, Aurora, Colo.

Footnotes
Accepted for publication September 20, 1991.

The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense.

Presented at the American Thoracic Society Meeting, Anaheim, Calif, May 15, 1991.

Reprint requests to Pulmonary/Critical Care Medicine, Fitzsimons Army Medical Center, Aurora, CO 80045 (Dr Ouellette).

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