Amantadine-Resistant Influenza A in a Nursing Facility

doi:10.1001/archinte.1992.00400140128027

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Vol. 152 No. 2, FEBRUARY 1992

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Amantadine-Resistant Influenza A in a Nursing Facility

John Degelau, MD; Salma K. Somani, PharmD; Susan L. Cooper, MS; David R. P. Guay, PharmD; Kent B. Crossley, MD

Arch Intern Med. 1992;152(2):390-392.

Abstract

Rapid index case treatment and amantadine prophylaxis were implementedin two nursing homes exposed to influenza A. Facility A hadno isolation of cases, and 18 of 22 cases occurred after amantadinehydrochloride therapy was initiated. Three patients exhibitedamantadine-resistant virus. Facility B had day 1 isolation ofthe index case. A facility-wide outbreak did not occur. Theexperience of these facilities suggests that concurrent amantadinetreatment and prophylaxis without adequate case isolation maypromote further influenza A infection in a nursing facility.

(Arch Intern Med. 1992;152:390-392)

Author Affiliations

From the Section of Geriatric Medicine, Department of Internal Medicine (Drs Degelau and Crossley), and the Section of Clinical Pharmacy (Drs Somani, Guay, and Ms Cooper), St Paul-Ramsey Medical Center, St Paul, Minn.

Footnotes

Accepted for publication August 6, 1991.

Reprint requests to Department of Internal Medicine, 640 JacksonSt, St Paul, MN 55101 (Dr Degelau).

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