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John Degelau, MD; Salma K. Somani, PharmD; Susan L. Cooper, MS; David R. P. Guay, PharmD; Kent B. Crossley, MD

Arch Intern Med. 1992;152(2):390-392.

Abstract
Rapid index case treatment and amantadine prophylaxis were implemented in two nursing homes exposed to influenza A. Facility A had no isolation of cases, and 18 of 22 cases occurred after amantadine hydrochloride therapy was initiated. Three patients exhibited amantadine-resistant virus. Facility B had day 1 isolation of the index case. A facility-wide outbreak did not occur. The experience of these facilities suggests that concurrent amantadine treatment and prophylaxis without adequate case isolation may promote further influenza A infection in a nursing facility.

(Arch Intern Med. 1992;152:390-392)

Author Affiliations
From the Section of Geriatric Medicine, Department of Internal Medicine (Drs Degelau and Crossley), and the Section of Clinical Pharmacy (Drs Somani, Guay, and Ms Cooper), St Paul-Ramsey Medical Center, St Paul, Minn.

Footnotes
Accepted for publication August 6, 1991.

Reprint requests to Department of Internal Medicine, 640 Jackson St, St Paul, MN 55101 (Dr Degelau).

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