Rochalimaea henselae Causes Bacillary Angiomatosis and Peliosis Hepatis

doi:10.1001/archinte.1992.00400150114021

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Vol. 152 No. 3, MARCH 1992

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Rochalimaea henselae Causes Bacillary Angiomatosis and Peliosis Hepatis

Leonard N. Slater, MD; David F. Welch, PhD; Kyung-Whan Min, MD

Arch Intern Med. 1992;152(3):602-606.

Abstract

Background. —
Recent studies have demonstrated that a newly described agentof persistent bacteremia, Rochalimaea henselae, and the agentof bacillary angiomatosis are both closely related to Rochalimaeaquintana. Bacillary peliosis hepatis seemed likely to have thesame etiologic agent as bacillary angiomatosis. We sought thesepathologic changes in patients from whom R henselae was cultivated.

Methods. —
For two patients whose histopathologic findings we reviewed,additional light and electron microscopy were performed. Theirbacterial isolates were compared by electrophoretic patternsof outer membrane proteins, restriction endonuclease digestionpatterns of DNA, and reaction with murine antiserum.

Results.——
A previously reported human immunodeficiency virus—infectedman with persistent bacteremia due to R henselae was found tohave bacillary peliosis hepatis. Rochalimaea henselae was alsoisolated from the spleen of a woman receiving immunosuppressivetherapy after allogeneic renal transplantation. She had developedfever, liver and spleen nodules, and periaortic lymphadenopathy.Bacillary peliosis of her liver and spleen, as well as bacillaryangiomatosis of liver, spleen, and a lymph node, were found.The bacterial isolates had comparable electrophoretic patternsof outer membrane proteins and of restriction endonuclease—digestedDNA, which differed from the respective patterns of R quintana.Murine antisera raised to the first isolate reacted stronglywith the second by means of immunoblot and immunofluorescencetechniques, while reacting only weakly with R quintana.

Conclusion.——
Rochalimaea henselae, recently recognized to cause persistentfever and bacteremia in immunocompetent and immunocompromisedpersons, also causes bacillary angiomatosis and parenchymalbacillary peliosis.

(Arch Intern Med. 1992;152:602-606)

Author Affiliations

From the Departments of Medicine (Dr Slater), Pediatrics (Dr Welch), and Pathology (Dr Min), University of Oklahoma College of Medicine, and the Medicine Service, Department of Veterans Affairs Medical Center (Dr Slater), Oklahoma City.

Footnotes

Accepted for publication September 9, 1991.

Reprint requests to Infectious Diseases Section (111-C), 921NE 13th St, Oklahoma City, OK 73104 (Dr Slater).

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