This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Report of Four Cases and Review of the Literature

Gary R. Gibson, MD; Eric B. Whitacre, MD; Carlos A. Ricotti, MD

Arch Intern Med. 1992;152(3):625-632.

Abstract
In four patients, ulcerative disease of the colon developed while they were taking nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical presentation and laboratory and colonoscopic findings were similar to those of inflammatory bowel disease. Review of the literature disclosed 74 additional cases of NSAID-induced colitis in adults. This is a rare but serious, sometimes fatal, complication of NSAID therapy. The elderly and those taking long-term NSAID therapy appear to be at highest risk. The pathogenesis is thought to be related to inhibition of intestinal prostaglandin synthesis. Whether some NSAIDs are more likely to induce colitis than others is not known. Since NSAIDs are so widely prescribed and some are available without a prescription, heightened awareness by physicians and the lay public will be important in reducing injury from this disease, both by prevention and earlier recognition.

(Arch Intern Med. 1992;152:625-632)

Author Affiliations
From the Departments of Medicine (Drs Gibson and Ricotti) and Surgery (Dr Whitacre), Trumbull Memorial Hospital, Warren, Ohio.

Footnotes
Accepted for publication July 31, 1991.

Reprint requests to 1651 E Market St, Warren, OH 44483 (Dr Gibson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Is there an association between intestinal perfusion and Crohn's disease activity? A feasibility study using contrast-enhanced ultrasound
KUMAR et al.
Br. J. Radiol. 2009;82:112-117.
ABSTRACT | FULL TEXT  

CD4+ T cells from IL-10-deficient mice transfer susceptibility to NSAID-induced Rag colitis
Blum et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 2004;287:G320-G325.
ABSTRACT | FULL TEXT  

Non-steroidal anti-inflammatory drugs as a risk factor for acute diarrhoea: a case crossover study
Etienney et al.
Gut 2003;52:260-263.
ABSTRACT | FULL TEXT  

Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs
Smecuol et al.
Gut 2001;49:650-655.
ABSTRACT | FULL TEXT  

Use of nonsteroidal anti-inflammatory drugs in cancer
Pace
Palliat Med 1995;9:273-286.
ABSTRACT  

Striking Prevalence of Over-the-Counter Nonsteroidal Anti-inflammatory Drug Use in Patients With Upper Gastrointestinal Hemorrhage
Wilcox et al.
Arch Intern Med 1994;154:42-46.
ABSTRACT