This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Lee J Hixson, MD; Catherine L. Kelley, PharmD; William N. Jones, MS; Craig D. Tuohy, MD

Arch Intern Med. 1992;152(4):726-732.

Abstract
A variety of options are available for the medical treatment of peptic ulcer disease, including antacids, histamine₂ receptor antagonists, omeprazole, prostaglandin analogues, and sucralfate and bismuth formulations. Seventy percent to 90% of peptic duodenal and gastric ulcers will heal after 4 to 8 weeks of therapy. Combination regimens using these agents have not been demonstated to be superior to singleagent therapy. Aggressive acid suppression with "highdose" histamine2 receptor antagonists or omeprazole accelerates healing of ordinary ulcers and promotes healing of previously refractory ulcers. Although ulcer recurrence is diminished by continuous "maintenance" therapy with the aforementioned agents, recurrence seems to be dramatically suppressed after eradication of Helicobacter pylori from the gastroduodenal mucosa.

(Arch Intern Med. 1992;152:726-732)

Author Affiliations
From the Medical (Drs Hixson and Tuohy) and Pharmacy (Dr Kelley and Mr Jones) Services, Veterans Affairs Medical Center and Colleges of Medicine and Pharmacy, University of Arizona, Tucson.

Footnotes
Accepted for publication August 27, 1991.

Reprint requests to University Medical Center, GI Section, Room 6406, 1501 N Campbell Ave, Tucson, AZ 85724 (Dr Hixson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Helicobacter pylori
Fennerty
Arch Intern Med 1994;154:721-727.
ABSTRACT