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Zidovudine-Induced Leukocytoclastic Vasculitis
Ramon A. Torres, MD;
Robert Y. Lin, MD;
Moon Lee, MD;
Michael R. Barr
Arch Intern Med. 1992;152(4):850-851.
Abstract
Cutaneous reactions, including acne, pruritus, urticaria, and nail dyschromia, have been associated with zidovudine use. Cutaneous leukocytoclastic vasculitis is characterized by distinctive patterns of dermal perivascular inflammation without visceral involvement. We treated two cases of cutaneous leukocytoclastic vasculitis associated with fever in patients with severe human immunodeficiency virus— related immunodeficiency in which symptoms resolved on withdrawal of zidovudine therapy and recurred after rechallenge with the drug. This unusual hypersensitivity reaction to zidovudine is probably related to the immune dysregulation and the propensity toward allergic phenomena found in human immunodeficiency virus infection.
(Arch Intern Med. 1992;152:850-851)
Author Affiliations
From the Department of Medicine, St Vincent's Hospital and Medical Center of New York (NY).
Footnotes
Accepted for publication August 27, 1991.
Reprint requests to AIDS Center, Department of Medicine, St Vincent's Hospital and Medical Center, 153 W 11th St, New York, NY 10011 (Dr Torres).
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