This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Martin G. Myers, MD, FRCPC; Antoni Basinski, MD, PhD, CCFP

Arch Intern Med. 1992;152(9):1767-1772.

Abstract
Objective.—
We determined if coffee consumption is associated with an increased risk of developing coronary heart disease.

Data Identification.—
Articles published between 1966 and August 1991 examining a possible link between coffee and coronary heart disease were identified by a computeraided literature search (Medline) and by standard bibliographic searches.

Study Selection.—
All prospective cohort studies providing data on daily coffee consumption and coronary events (acute myocardial infarction and/or coronary death) were included.

Data Extraction.—
Data from each published article were extracted. Additional unpublished data augmenting those published for one study were also included. Each cohort was categorized by reported daily coffee consumption. Incidence of coronary events at each level of coffee consumption was the primary outcome.

Results.—
Eleven prospective studies were included. The coronary events for subjects consuming little or no coffee (1 cup per day) were compared with event rates for those consuming greater amounts of coffee. The studies exhibited heterogeneity of results. The typical odds ratios and 95% confidence intervals across studies were estimated by logistic regression analysis. Coffee intake from 1 to 4 cups per day was not associated with any increase in coronary heart disease occurrence compared with 1 cup or less per day (odds ratio, 1.01; confidence interval [0.93,1.11]). The odds ratios for 4 to 6 and 6 cups or more per day compared with up to 1 cup per day were 1.01 (0.90,1.12) and 1.09 (0.97,1.22), respectively.

Conclusions.—
There is no association between coffee consumption and the occurrence of coronary heart disease. This conclusion holds in the absence of adjustment for other coronary risk factors.

(Arch Intern Med. 1992;152:1767-1772)

Author Affiliations
From the Departments of Medicine (Dr Myers) and Clinical Epidemiology (Dr Basinski), Sunnybrook Health Science Centre and Departments of Medicine (Dr Myers) and Family and Community Medicine (Dr Basinski), University of Toronto, Ontario.

Footnotes
Accepted for publication March 20, 1992.

Reprint requests to the Division of Cardiology, Sunnybrook Health Science Centre, 2075 Bayview Ave, Toronto, Ontario, Canada M4N 3M5 (Dr Myers).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Coffee Consumption and Coronary Calcification: The Rotterdam Coronary Calcification Study
van Woudenbergh et al.
Arterioscler. Thromb. Vasc. Bio. 2008;28:1018-1023.
ABSTRACT | FULL TEXT  

Coffee Consumption and Risk of Cardiovascular Events After Acute Myocardial Infarction: Results From the GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico)-Prevenzione Trial
Silletta et al.
Circulation 2007;116:2944-2951.
ABSTRACT | FULL TEXT  

Coffee Consumption and Risk of Myocardial Infarction among Older Swedish Women
Rosner et al.
Am J Epidemiol 2007;165:288-293.
ABSTRACT | FULL TEXT  

Coffee Consumption and Coronary Heart Disease in Men and Women: A Prospective Cohort Study
Lopez-Garcia et al.
Circulation 2006;113:2045-2053.
ABSTRACT | FULL TEXT  

Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction
Cornelis et al.
JAMA 2006;295:1135-1141.
ABSTRACT | FULL TEXT  

Coffee Drinking Is Dose-Dependently Related to the Risk of Acute Coronary Events in Middle-Aged Men
Happonen et al.
J. Nutr. 2004;134:2381-2386.
ABSTRACT | FULL TEXT  

Effect of Caffeine on Blood Pressure Beyond the Laboratory
Myers
Hypertension 2004;43:724-725.
FULL TEXT  

Misclassification of Exposure: Coffee as a Surrogate for Caffeine Intake
Brown et al.
Am J Epidemiol 2001;153:815-820.
ABSTRACT | FULL TEXT  

Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
Fredholm et al.
Pharmacol. Rev. 1999;51:83-133.
ABSTRACT | FULL TEXT  

Coffee Consumption and Coronary Heart Disease in Women: A Ten-Year Follow-up
Willett et al.
JAMA 1996;275:458-462.
ABSTRACT  

The Relationship of Coffee Consumption to Various Self-Reported Cardiovascular Events in Middle-Aged Norwegian Men and Women
Stensvold and Tverdal
Scand J Public Health 1995;23:103-109.
ABSTRACT  

Coffee and Coronary Heart Disease
Klatsky et al.
Arch Intern Med 1993;153:902-902.
ABSTRACT  

Coffee and Coronary Heart Disease-Reply
Basinski and Myers
Arch Intern Med 1993;153:902-902.
ABSTRACT