Infections due to Penicillin-Resistant Pneumococci: Clinical, Epidemiologic, and Microbiologic Features

doi:10.1001/archinte.1993.00410110013003

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Vol. 153 No. 11, 14 JUNE 1993

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Infections due to Penicillin-Resistant Pneumococci

Clinical, Epidemiologic, and Microbiologic Features

Gregory M. Caputo, MD; Peter C. Appelbaum, MD; Hans H. Liu, MD

Arch Intern Med. 1993;153(11):1301-1310.

Abstract

Pneumococcal infection remains a common cause of serious morbidityand mortality throughout the world. Until recently, clinicalisolates of pneumococci that were penicillin resistant wererare. However, 4% to 5% of the clinical isolates in the UnitedStates were recently found to be either intermediately resistantor highly resistant to penicillin. Clinicians in every fieldof medicine must therefore be better informed regarding penicillin-resistantpneumococcal infections to minimize their attendant morbidityand mortality and increase compliance with preventive measures.We reviewed the molecular, genetic, and epidemiologic aspectsof penicillin-resistant pneumococcal infections, with emphasison their microbiologic and clinical features.

Author Affiliations

From the Departments of Medicine (Dr Caputo) and Pathology (Dr Appelbaum), Pennsylvania State University College of Medicine, Hershey; and Division of Infectious Disease, Presbyterian Medical Center, Philadelphia, Pa (Dr Liu).

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