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Jon R. Doud, MD; Mary M. McCabe, MS, CCRN; Alvaro Montoya, MD; Edward R. Garrity, Jr, MD

Arch Intern Med. 1993;153(24):2769-2773.

Abstract
Background
We reviewed our experience with isolated lung transplantation at Loyola University Medical Center, Maywood, Ill. From April 1990 through June 1992, 33 lung transplantations for end-stage pulmonary disease were performed (30 single lung, three bilateral single lung). Recipient diagnoses include chronic obstructive pulmonary disease, ₁-antiprotease deficiency, pulmonary fibrosis, primary pulmonary hypertension, Eisenmenger's syndrome, sarcoidosis, cystic fibrosis, bronchiectasis, and bronchiolitis obliterans.

Methods
For patients who underwent transplantation for end-stage obstructive airway disease, we retrospectively reviewed functional indexes before and after transplantation. In addition, the overall survival rate was determined.

Results
Successful transplantation resulted in a marked improvement in functional capacity. Singlelung transplantation for end-stage obstructive airway disease resulted in a threefold improvement in the 1-second forced expiratory volume, from 0.49 to 1.64 L. The actual survival for all isolated lung transplant recipients (including both single-lung and bilateral single-lung procedures) was 73%, with a 15% 30-day mortality.

Conclusion
Isolated lung transplantation can significantly improve functional capacity as well as the quality of life in patients with end-stage lung disease.

(Arch Intern Med. 1993;153:2769-2773)

Author Affiliations
From the Loyola University Lung Transplantation Group; and Departments of Medicine (Drs Doud and Garrity) and Thoracic and Cardiovascular Surgery (Ms McCabe and Dr Montoya), Loyola University of Chicago, Stritch School of Medicine, Maywood, Ill.

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