 |
|
Cigarette Smoking and Adult LeukemiaA Meta-analysis
Ross C. Brownson, PhD;
Thomas E. Novotny, MD;
Michael C. Perry, MD
Arch Intern Med. 1993;153(4):469-475.
Abstract
Background
Increasing evidence suggests that certain forms of adult leukemia may be related to cigarette smoking.
Methods
To evaluate the association between cigarette smoking and adult leukemia, we conducted a metaanalysis of available studies. Data were identified through an English-language MEDLINE search for the period 1970 through 1992 and through our knowledge of ongoing and unpublished studies. Among the studies identified, the meta-analysis included seven prospective studies and eight case-control studies. The US Surgeon General's criteria were used to assess the evidence for causality.
Results
A positive association between smoking and certain histologic types of leukemia was found in both prospective and case-control studies. The summary smoking-related risk derived from prospective studies (relative risk, 1.3; 95% confidence interval, 1.3 to 1.4) was greater than that based on case-control data (relative risk, 1.1; 95% confidence interval, 1.0 to 1.2). Prospective data suggested an elevated risk of myeloid leukemia associated with cigarette smoking (relative risk, 1.4; 95% confidence interval, 1.2 to 1.6). Pooled case-control data showed increased smoking-associated risk for acute nonlymphocytic leukemia (relative risk, 1.3; 95% confidence interval, 1.1 to 1.5). Risk of leukemia increased according to the number of cigarettes smoked per day. Population-attributable risk calculations suggested that approximately 14% of all US leukemia cases (including 17% of myeloid and 14% of acute nonlymphocytic leukemias) may be due to cigarette smoking.
Conclusions
The consistency, temporality, and biologic plausibility of this relationship augment our findings, which support a causal relationship between cigarette smoking and certain forms of adult leukemia. Further studies are needed to examine risk among women, dose-response effects, and variation in risk by histologic type.
(Arch Intern Med. 1993;153:469-475)
Author Affiliations
From the Division of Chronic Disease Prevention and Health Promotion, Missouri Department of Health, Columbia (Dr Brownson); Departments of Medicine (Drs Brownson and Perry) and Family and Community Medicine (Dr Brownson), University of Missouri School of Medicine, Columbia; Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga (Dr Novotny). Dr Novotny is now with the School of Public Health, University of California-Berkeley.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone
Martinelli et al.
Neurology 2011;77:1887-1895.
ABSTRACT
| FULL TEXT
A meta-analysis of leukaemia risk from protracted exposure to low-dose gamma radiation
Daniels and Schubauer-Berigan
Occup. Environ. Med. 2011;68:457-464.
ABSTRACT
| FULL TEXT
Diet, Lifestyle, and Acute Myeloid Leukemia in the NIH-AARP Cohort
Ma et al.
Am J Epidemiol 2010;171:312-322.
ABSTRACT
| FULL TEXT
Is There an Entity of Chemically Induced BCR-ABL-Positive Chronic Myelogenous Leukemia?
Lichtman
The Oncologist 2008;13:645-654.
ABSTRACT
| FULL TEXT
Is Family History of Breast Cancer a Marker of Susceptibility to Exposures in the Incidence of de Novo Adult Acute Leukemia?
Rauscher et al.
Cancer Epidemiol. Biomarkers Prev. 2003;12:289-294.
ABSTRACT
| FULL TEXT
Influence of cigarette smoking on the presentation and course of acute myeloid leukemia
Chelghoum et al.
Ann Oncol 2002;13:1621-1627.
ABSTRACT
| FULL TEXT
Smoking and Risk of Acute Myeloid Leukemia: Results from a Los Angeles County Case-Control Study
Pogoda et al.
Am J Epidemiol 2002;155:546-553.
ABSTRACT
| FULL TEXT
Are occupational, hobby, or lifestyle exposures associated with Philadelphia chromosome positive chronic myeloid leukaemia?
Bjork et al.
Occup. Environ. Med. 2001;58:722-727.
ABSTRACT
| FULL TEXT
Does Cigarette Smoking Lead to the Subsequent Development of Leukemia?
Severson and Linet
Arch Intern Med 1993;153:425-427.
ABSTRACT
|
