This Article  • References  • Full text PDF  • Correction  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Jose M. Santiago, MD; James E. Dalen, MD

Arch Intern Med. 1994;154(12):1317-1321.

Abstract
Despite significant increases in the incidence of myocardial infarction, reduction of total mortality as a result of cholesterol-lowering programs has not been demonstrated. This puzzling outcome has led to several hypotheses linking cholesterol levels and mortality due to accidents, suicide, and homicide. We review the proposed explanations for increased mortality due to violent deaths. We discuss the available evidence and conclude that while there are some intriguing findings based on the well-established relationship between violent behavior and serotonin activity, the necessary link between cholesterol, serotonin, and violence has not been demonstrated. The complexity of the observed violent behaviors and their multiple determinants defies a simple explanation at the present time.

(Arch Intern Med. 1994;154:1317-1321)

Author Affiliations
From the Department of Psychiatry (Dr Santiago), University of Arizona College of Medicine, Tucson. Dr Dalen is Vice Provost for Health Sciences and Dean of the University of Arizona College of Medicine.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Dietary Manganese Intake and Type of Lipid Do Not Affect Clinical or Neuropsychological Measures in Healthy Young Women
Finley et al.
J. Nutr. 2003;133:2849-2856.
ABSTRACT | FULL TEXT  

Long-term Assessment of Psychological Well-being in a Randomized Placebo-Controlled Trial of Cholesterol Reduction With Pravastatin
Stewart et al.
Arch Intern Med 2000;160:3144-3152.
ABSTRACT | FULL TEXT  

Relations of Trait Depression and Anxiety to Low Lipid and Lipoprotein Concentrations in Healthy Young Adult Women
Suarez
Psychosom. Med. 1999;61:273-279.
ABSTRACT | FULL TEXT  

Low Cholesterol and Violence
Mufti et al.
Psychiatr. Serv. 1998;49:221-224.
ABSTRACT | FULL TEXT  

Lack of Relations of Hostility, Negative Affect, and High-Risk Behavior With Low Plasma Lipid Levels in the Coronary Artery Risk Development in Young Adults Study
Markovitz et al.
Arch Intern Med 1997;157:1953-1959.
ABSTRACT  

Does Lowering Cholesterol Cause Cancer?
Dalen and Dalton
JAMA 1996;275:67-69.
ABSTRACT  

Lowering High Plasma Cholesterol Levels Is Not Dangerous
Schwandt et al.
Arch Intern Med 1995;155:985-985.
ABSTRACT  

Cholesterol and Violent Behavior
Serjeant
Arch Intern Med 1995;155:544-544.
ABSTRACT  

Neurobiology of Cholesterol and Violent Behavior
Friedman
Arch Intern Med 1995;155:543-544.
ABSTRACT