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Implications for Renal Survival

MAJ Kevin C. Abbott, MC; COL Leonard R. Sanders, MC; George L. Bakris, MD

Arch Intern Med. 1994;154(2):146-153.

Abstract
Microvascular and macrovascular disease cause considerable mortality and morbidity both among patients with non—insulin-dependent diabetes mellitus and those with insulin-dependent diabetes mellitus. Furthermore, non—insulin-dependent and insulin-dependent diabetes mellitus overlap in their pathogenesis as well as shortand long-term complications. In the diabetic patient, genetic susceptibility as well as other factors, ie, microalbuminuria, hypertension, high protein intake, blood glucose control, etc, ultimately culminate in a diffuse disease process, eg, diabetic vascular and/or renal disease. Early predictors of susceptibility for development of renal disease in diabetic subjects would help focus our treatment strategies. The role of microalbuminuria as a prognostic marker for the major complications of insulin-dependent diabetes mellitus has been previously reviewed. We reviewed the role of microalbuminuria as a prognostic marker for progression of diabetic renal disease in subjects with non—insulin-dependent diabetes mellitus. We examined treatment strategies to lower microalbuminuria and its associated impact on disease progression.

(Arch Intern Med. 1994;154:146-153)

Author Affiliations
USA; USA

From the Departments of Medicine, Divisions of Nephrology, Brooke Army Medical Center, Fort Sam Houston, Tex (Drs Abbott and Sanders), and the University of Texas Health Science Center, San Antonio (Dr Bakris). Dr Bakris is now with the Departments of Preventive and Internal Medicine, Divisions of Nephrology and Endocrinology, Rush Medical College, Chicago, Ill.

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