Management of Adverse Reactions to Trimethoprim-Sulfamethoxazole in Human Immunodeficiency Virus--Infected Patients

doi:10.1001/archinte.1994.00420210028004

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Vol. 154 No. 21, 14 November 1994

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Management of Adverse Reactions to Trimethoprim-Sulfamethoxazole in Human Immunodeficiency Virus—Infected Patients

Alan C. Jung, MD; Douglas S. Paauw, MD

Arch Intern Med. 1994;154(21):2402-2406.

Abstract

Trimethoprim-sulfamethoxazole is an important medication forthe treatment and prevention of Pneumocystis carinii pneumoniain patients with the acquired immunodeficiency syndrome. Useof this medication has been limited by the high frequency ofadverse reactions that occur in patients with human immunodeficiencyvirus disease. This article reviews the incidence and spectrumof adverse reactions and options for continuing therapy withtrimethoprim-sulfamethoxazole in human immunodeficiency virus—infectedpatients who have adverse reactions. (Arch Intern Med. 1994;154:2402-2406)

Author Affiliations

From the Department of Medicine, University of Washington, Seattle.

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