This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Richard M. Hoffman, MD, MPH; Harinder S. Garewal, MD, PhD

Arch Intern Med. 1995;155(3):241-246.

Abstract
Oxygen-free radical reactions have been implicated in many chronic disease processes, including atherosclerotic cardiovascular disease. Recent studies of lipid metabolism have suggested that oxidative modification of low-density lipoprotein accelerates atherogenesis. Micronutrient antioxidants, including -tocopherol and β-carotene, however, can neutralize oxygen-free radicals and inhibit low-density lipoprotein oxidation. This review examines (1) the role of oxidized low-density lipoprotein in atherogenesis, (2) the association between nutritional antioxidant intake and atherosclerosis, and (3) observational and clinical trial data on the effect of antioxidants in reducing the risk of coronary heart disease. While evidence suggests that antioxidant supplements protect against coronary heart disease, definitive recommendations await results from ongoing randomized trials of primary and secondary prevention.

(Arch Intern Med. 1995;155:241-246)

Author Affiliations
From the Departments of Medicine, University of Arizona Health Sciences Center (Drs Hoffman and Garewal), and Tucson Veterans Affairs Medical Center (Dr Garewal).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Influence of supplemental magnesium, tryptophan, vitamin C, and vitamin E on stress responses of pigs to vibration
Peeters et al.
J ANIM SCI 2005;83:1568-1580.
ABSTRACT | FULL TEXT  

Statistical Inference for the Area under the Receiver Operating Characteristic Curve in the Presence of Random Measurement Error
Schisterman et al.
Am J Epidemiol 2001;154:174-179.
ABSTRACT | FULL TEXT  

Development of a case-based integrated nutrition curriculum for medical students
Hark and Morrison
Am. J. Clin. Nutr. 2000;72 :890S-897S.
ABSTRACT | FULL TEXT  

Modified LDL–Mediated Increases in Endothelial Layer Permeability Are Attenuated With 17ß-Estradiol
Gardner et al.
Arterioscler. Thromb. Vasc. Bio. 1999;19:854-861.
ABSTRACT | FULL TEXT  

The Role of Antioxidants on Risk for Cardiovascular Disease
Anand et al.
Arch Intern Med 1995;155:1685-1686.
ABSTRACT