Effects of Acute Psychological Stress on Serum Lipid Levels, Hemoconcentration, and Blood Viscosity

doi:10.1001/archinte.1995.00430060077009

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Vol. 155 No. 6, 27 MARCH 1995

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Effects of Acute Psychological Stress on Serum Lipid Levels, Hemoconcentration, and Blood Viscosity

Matthew F. Muldoon, MD; Tracy B. Herbert, PhD; Stephen M. Patterson, PhD; Marina Kameneva, PhD; Robert Raible; Stephen B. Manuck, PhD

Arch Intern Med. 1995;155(6):615-620.

Abstract

Background
While there is substantial evidence that psychological stressenhances risk for coronary artery disease, the mechanisms underlyingsuch an influence remain unclear. We examined the effects ofshort-term psychological stress on serum lipid levels, hemoconcentration,fibrinogen level, and plasma viscosity.

Methods
Forty-four healthy young adults were randomly assigned to performa distinctly frustrating cognitive task for 20 minutes (stresscondition) or to rest quietly for the same period (control condition).

Results
Relative to controls, stressed subjects showed significant increasesin blood pressure and heart rate; total, low-density, and high-densitylipoprotein cholesterol levels; hematocrit; hemoglobin level;and total protein concentration. Stressed subjects also showedsignificant reductions in plasma volume and increased plasmaviscosity and estimated whole-blood viscosity compared withcontrols. A similar trend in fibrinogen level was not statisticallysignificant. Individual differences in blood pressure and heartrate response to stress correlated highly with changes in totalcholesterol levels and hematocrit.

Conclusions
Our investigation provides further evidence that exposure toshort-term mental stress elicits hemoconcentration with associatedincreases in serum lipid concentrations, hemostatic factors,and blood viscosity.

(Arch Intern Med. 1995;155:615-620)

Author Affiliations

From the Center for Clinical Pharmacology, University of Pittsburgh (Pa) School of Medicine (Dr Muldoon); the Department of Psychology, Carnegie Mellon University, Pittsburgh (Dr Herbert); the Behavioral Physiology Laboratory, Department of Psychology (Drs Patterson and Manuck and Mr Raible), and the Department of Surgery (Dr Kameneva), University of Pittsburgh School of Medicine.

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