This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (47)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Diagnosis and Management

William G. Simpson, MD

Arch Intern Med. 1995;155(8):798-803.

Abstract
Gastroesophageal reflux is common among asthmatics. It not only may worsen during an episode of airways obstruction but also may serve as a trigger for such an attack. Both animal and clinical data suggest that gastroesophageal reflux serves as a trigger of bronchospasm, potentiates the bronchomotor response to additional triggers, or both. Patients with reflux-associated asthma may manifest symptoms of gastroesophageal reflux, either classic or atypical, but approximately 25% to 30% have clinically silent reflux. Despite the use of inadequate doses of acid-suppressive medicines, clinical trials have documented improvement in respiratory symptoms among asthmatics following the treatment of reflux. Recent trials suggest long-term improvement in respiratory symptoms following antireflux surgery. Selected patients with asthma should be evaluated for gastroesophageal reflux. If it is present, such patients may benefit from aggressive antireflux therapy.

(Arch Intern Med. 1995;155:798-803)

Author Affiliations
From the Division of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington. Dr Simpson is now with East Texas Grastrenterology Associates and Good Shepherd Medical Center, Longview.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Obesity, waist size and prevalence of current asthma in the California Teachers Study cohort
Von Behren et al.
Thorax 2009;64:889-893.
ABSTRACT | FULL TEXT  

Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma
The American Lung Association Asthma Clinical Rese
NEJM 2009;360:1487-1499.
ABSTRACT | FULL TEXT  

Does Helicobacter pylori protect against asthma and allergy?
Blaser et al.
Gut 2008;57:561-567.
FULL TEXT  

Inverse Associations of Helicobacter pylori With Asthma and Allergy
Chen and Blaser
Arch Intern Med 2007;167:821-827.
ABSTRACT | FULL TEXT  

Mast cells and reactive oxygen species in citric acid-induced airway constriction
Wu et al.
J. Appl. Physiol. 2004;96:1879-1885.
ABSTRACT | FULL TEXT  

Pulmonary responses to tracheal or esophageal acidification in guinea pigs with airway inflammation
Lopes et al.
J. Appl. Physiol. 2002;93:842-847.
ABSTRACT | FULL TEXT  

Body Mass Index and Asthma in Adults in Families of Subjects with Asthma in Anqing, China
CELEDON et al.
Am. J. Respir. Crit. Care Med. 2001;164:1835-1840.
ABSTRACT | FULL TEXT  

Medical treatment for reflux oesophagitis does not consistently improve asthma control: a systematic review
Coughlan et al.
Thorax 2001;56:198-204.
ABSTRACT | FULL TEXT  

Prospective Study of Body Mass Index, Weight Change, and Risk of Adult-onset Asthma in Women
Camargo et al.
Arch Intern Med 1999;159:2582-2588.
ABSTRACT | FULL TEXT  

Bronchoconstriction Induced by Citric Acid Inhalation in Guinea Pigs . Role of Tachykinins, Bradykinin, and Nitric Oxide
RICCIARDOLO et al.
Am. J. Respir. Crit. Care Med. 1999;159:557-562.
ABSTRACT | FULL TEXT  

Increased Prevalence of Gastroesophageal Reflux in Patients with Idiopathic Pulmonary Fibrosis
TOBIN et al.
Am. J. Respir. Crit. Care Med. 1998;158:1804-1808.
ABSTRACT | FULL TEXT  

Asthma
Lemanske and Busse
JAMA 1997;278:1855-1873.
ABSTRACT