Beyond Low-Density Lipoprotein Cholesterol: A Perspective on Low High-Density Lipoprotein Disorders and Lp(a) Lipoprotein Excess

doi:10.1001/archinte.1996.00440110036006

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Vol. 156 No. 12, 24 JUNE 1996

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Beyond Low-Density Lipoprotein Cholesterol

A Perspective on Low High-Density Lipoprotein Disorders and Lp(a) Lipoprotein Excess

Robert S. Rosenson, MD

Arch Intern Med. 1996;156(12):1278-1284.

Abstract

Evidence supports the involvement of 2 common dyslipidemias-lowhigh-density lipoprotein disorders and Lp(a) lipoprotein excess—incoronary heart disease. Until clinical trials determine whetherspecific therapeutic interventions can prevent the occurrenceand recurrence of coronary heart disease in patients with thesedyslipidemias, the implementation of cholesterol-lowering guidelinescan provide a reasonable way to manage low highdensity lipoproteindisorders and to identify specific categories of patients whomay be at particularly high risk for premature coronary heartdisease. Empiric treatment guidelines are suggested for lowhigh-density lipoprotein disorders and Lp(a) lipoprotein excessin order to foster further discussion and validation by clinicaltrial data.

(Arch Intern Med. 1996;156:1278-1284)

Author Affiliations

From the Preventive Cardiology Center, Rush-Presbyterian-St Luke's Medical Center, Chicago, lll.

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