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Effects on Airway Function in Patients With Asthma

William W. Busse, MD

Arch Intern Med. 1996;156(14):1514-1520.

Abstract
Inhaled β-adrenergic agonist bronchodilators are integral components of effective asthma treatment. However, the risk of asthma morbidity and mortality associated with the regular use of certain inhaledβ-agonists was first noted in the United Kingdom during the 1960s and in New Zealand during the 1970s. There are also concerns that long-term use of both long-acting and short-acting inhaled β-agonists may cause a loss of asthma control in some patients. These experiences have caused some investigators to question the safety of inhaled β-agonists in patients with asthma. This review attempts to address these issues, which are of concern to both physicians and patients alike, and aims to increase the clinician's understanding and awareness of the problems and treatment options.

Arch Intern Med. 1996;156:1514-1520

Author Affiliations
From the Department of Medicine, Section of Allergy and Immunology, University of Wisconsin Medical School, Madison.

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