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A Novel Side Effect of Antithyroid Drugs

Satoru Suzuki, MD; Kazuo Ichikawa, MD; Minoru Nagai, MD; Michiaki Mikoshiba, MD; Jun-ichiro Mori, MD; Atsuko Kaneko, MD; Rieko Sekine, MD; Nahoko Asanuma, MD; Masahiro Hara, MD; Yutaka Nishii, MD; Keishi Yamauchi, MD; Toru Aizawa, MD; Kiyoshi Hashizume, MD

Arch Intern Med. 1997;157(6):693-696.

Abstract
We describe 4 patients with Graves disease who had abnormal increases of serum creatine kinase (CK) concentrations during treatment with antithyroid medications. Three of the patients experienced myalgia and muscle cramps. All of the patients manifested an increase in serum CK levels 1 to 3 months after the administration of antithyroid drugs. Thyrotropin concentrations and cardiac systolic time indexes during the elevation of serum CK concentrations were not consistent with hypothyroidism. The mechanisms are not obvious, but it is likely that the rapid decrease of thyroid hormones in tissues may temporarily cause hypothyroid states, resulting in alterations in CK concentrations. It is suggested that hasty correction of thyrotoxicosis should be avoided in susceptible patients, unless the thyrotoxic conditions are critical.

Arch Intern Med. 1997;157:693-696

Author Affiliations
From the Department of Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan.

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