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Are Genetic Influences on Peptic Ulcer Dependent or Independent of Genetic Influences for Helicobacter pylori Infection?
Hoda M. Malaty, MD, PhD;
David Y. Graham, MD;
Inger Isaksson, BA;
Lars Engstrand, MD;
Nancy L. Pedersen, PhD
Arch Intern Med. 2000;160:105-109.
Background Genetic factors play a role or roles in the etiology of peptic ulcer disease and the acquisition of Helicobacter pylori infection.
Objective To evaluate the relative importance of genetic and environmental influences as well as the importance of H pylori on peptic ulcer disease.
Design Cross-sectional study on monozygotic (MZ) and dizygotic (DZ) twins, reared apart or together.
Participants Twins of the subregistry of the Swedish Twin Registry included in the Swedish Adoption/Twin Study of Aging.
Measurements Peptic ulcer disease and H pylori status were assessed in MZ and DZ twin pairs reared apart or together. A total of 258 twin pairs had information regarding H pylori status and history of peptic ulcer. Helicobacter pylori status was assessed as the presence of anti–H pylori IgG.
Results The intraclass correlations for peptic ulcer disease for MZ twins reared apart and together and DZ twins reared apart and together were 0.67, 0.65, 0.22, and 0.35, respectively, which indicates that genetic effects are important for liability to peptic ulcer. The correlation coefficient for MZ twins reared apart (0.67) provides the best single estimate of the relative importance of genetic effects (heritability) for variation in liability to peptic ulcer disease, and structural model fitting analyses confirmed this result (heritability, 62%). The cross-twin cross-trait correlations for MZ and DZ twins were examined to determine whether genetic effects for peptic ulcer were shared with or independent of genetic influences for H pylori. The cross-correlations for MZ and DZ twins were almost identical (0.25 and 0.29, respectively), suggesting that familial environmental rather than genetic influences mediate the association between peptic ulcer disease and H pylori infection.
Conclusions Genetic influences are of moderate importance for liability to peptic ulcer disease. Genetic influences for peptic ulcer are independent of genetic influences important for acquiring H pylori infection.
From the Department of Medicine (Drs Malaty and Graham) and Division of Molecular Virology (Dr Graham), Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; Division of Genetic Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (Ms Isaksson and Dr Pedersen); Department of Clinical Microbiology, University Hospital, Uppsala, Sweden (Dr Engstrand); and Department of Psychology, University of Southern California, Los Angeles (Dr Pedersen).
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