 |
|
Impact of Helicobacter pylori Infection on Gastric Cancer Incidence in a General Japanese Population
The Hisayama Study
Hajime Yamagata, MD;
Yutaka Kiyohara, MD;
Kunihiko Aoyagi, MD;
Isao Kato, MD;
Hiromitsu Iwamoto, MD;
Keizo Nakayama, MD;
Haruki Shimizu, MD;
Yumihiro Tanizaki, MD;
Hisatomi Arima, MD;
Noriyasu Shinohara, MD;
Hideki Kondo, MD;
Takayuki Matsumoto, MD;
Masatoshi Fujishima, MD
Arch Intern Med. 2000;160:1962-1968.
Background Several nested case-control studies have reported the potentially causal relationship between Helicobacter pylori infection and the development of gastric cancer. However, there has been no prospective study evaluating this issue. The purpose of this study is to examine the impact of H pylori infection on gastric cancer occurrence in a general Japanese population (Hisayama, Japan) stratified according to sex, using a prospective study design.
Methods A total of 2602 subjects aged 40 years or older (1070 men; mean age, 57 years; 1532 women; mean age, 59 years) without a history of gastrectomy or gastric cancer were classified according to the status of the serum IgG antibodies to H pylori and observed prospectively for 9 years from 1988.
Results Infection of H pylori was more common in men (71.5%) than in women (62.5%; P<.001). The age-adjusted incidence of gastric cancer for men (5.3 per 1000 person-years) was 4-fold higher than that for women (1.3; P<.001). In men, the age-adjusted incidence of gastric cancer was significantly higher in the subjects with H pylori infection than in those without it (6.2 vs 2.5; relative risk, 2.59 [95% confidence interval, 1.03-6.50]), whereas no significant difference was observed in women (1.2 vs 1.1; relative risk, 0.99 [95% confidence interval, 0.36-2.68]). These results were similar even after controlling for other risk factors in multivariate analysis. It was estimated that 40.1% of gastric cancers for men in this cohort were attributable to H pylori infection.
Conclusion A significant relationship exists between infection with H pylori and subsequent occurrence of gastric cancer for men but not for women in this Japanese population.
From the Second Department of Internal Medicine, Faculty of Medicine, Kyushu University (Drs Yamagata, Kiyohara, Kato, Iwamoto, Nakayama, Shimizu, Tanizaki, Arima, Shinohara, Kondo, Matsumoto, and Fujishima), and the First Department of Internal Medicine, Faculty of Medicine, Fukuoka University (Dr Aoyagi), Fukuoka City, Japan.
RELATED ARTICLE
Archives of Internal Medicine Reader's Choice: Continuing Medical Education
Arch Intern Med. 2000;160(13):2068-2069.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study
Persson et al.
Carcinogenesis 2008;29:1042-1048.
ABSTRACT
| FULL TEXT
Effect of Helicobacter pylori Infection Combined with CagA and Pepsinogen Status on Gastric Cancer Development among Japanese Men and Women: A Nested Case-Control Study.
Sasazuki et al.
Cancer Epidemiol. Biomarkers Prev. 2006;15:1341-1347.
ABSTRACT
| FULL TEXT
The Serum Pepsinogen Test as a Predictor of Gastric Cancer: The Hisayama Study
Oishi et al.
Am J Epidemiol 2006;163:629-637.
ABSTRACT
| FULL TEXT
Combined Evaluation of Expressions of Cyclin E and p53 Proteins as Prognostic Factors for Patients with Gastric Cancer
Bani-Hani et al.
Clin. Cancer Res. 2005;11:1447-1453.
ABSTRACT
| FULL TEXT
Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis
Nakamura et al.
Gut 2002;51:485-489.
ABSTRACT
| FULL TEXT
Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts
Helicobacter and Cancer Collaborative Group
Gut 2001;49:347-353.
ABSTRACT
| FULL TEXT
H. pylori Infection and Gastric Cancer Incidence in Japan
JWatch Infect. Diseases 2000;2000:5-5.
FULL TEXT
H. pylori and Gastric Cancer in Japan: A Population Study
JWatch Gastroenterology 2000;2000:1-1.
FULL TEXT
H. pylori and Gastric Cancer Risk
JWatch General 2000;2000:3-3.
FULL TEXT
|
