This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (36)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Women's Health  • Menopause  • Review  • Alert me on articles by topic

Lori Mosca, MD, PhD

Arch Intern Med. 2000;160:2263-2272.

Coronary heart disease is the single leading cause of death in women and a significant cause of disability. Menopause adversely affects several risk factors for coronary heart disease, suggesting that hormones influence the risk of coronary heart disease in postmenopausal women. This article reviews the observational and clinical trial data evaluating the relation between cardiovascular disease and hormone replacement therapy. Biological mechanisms of estrogen and the impact of adding progestins are emphasized. Potential risks and benefits of therapy are discussed. The relative effects of other estrogen and lipid-lowering therapies for preventing coronary heart disease in postmenopausal women are highlighted.

From the New York-Presbyterian Hospital of Columbia and Cornell Universities, New York, NY.

RELATED ARTICLE

Archives of Internal Medicine Reader's Choice: Continuing Medical Education
Arch Intern Med. 2000;160(15):2404.
FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hormone Replacement Therapy and the Cardiovascular System: Lessons Learned and Unanswered Questions
Ouyang et al.
J Am Coll Cardiol 2006;47:1741-1753.
ABSTRACT | FULL TEXT  

Reproductive History in Women with Lower Limb Ischemia
Hultgren et al.
ANGIOLOGY 2004;55:373-383.
ABSTRACT  

Hormone Replacement Therapy and Its Relationship to Lipid and Glucose Metabolism in Diabetic and Nondiabetic Postmenopausal Women: Results from the Third National Health and Nutrition Examination Survey (NHANES III)
Crespo et al.
Diabetes Care 2002;25:1675-1680.
ABSTRACT | FULL TEXT  

Overview of gender aspects of cardiac syndrome X
Kaski
Cardiovasc Res 2002;53:620-626.
ABSTRACT | FULL TEXT  

Rationale and Overview of the Raloxifene Use for the Heart (RUTH) Trial
MOSCA
Ann. N. Y. Acad. Sci. 2001;949:181-185.
ABSTRACT | FULL TEXT  

Hormone Replacement Therapy and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association
Mosca et al.
Circulation 2001;104:499-503.
FULL TEXT  

Observational Data Do Not Establish Cause and Effect
Watts
Arch Intern Med 2001;161:772-772.
FULL TEXT  

The Role of HRT in Cardiovascular Disease
Rozenberg et al.
Arch Intern Med 2001;161:773-773.
FULL TEXT