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Wolfgang Raber, MD; Wolfgang Raffesberg; Martin Bischof, MD; Christian Scheuba, MD; Bruno Niederle, MD; Slobodan Gasic, MD; Werner Waldhäusl, MD; Michael Roden, MD

Arch Intern Med. 2000;160:2957-2963.

Background  Recently, measurement of plasma metanephrines was suggested to improve the detection of pheochromocytoma compared with the other common biochemical tests.

Objective  To examine the diagnostic precision of measurements of plasma metanephrines, plasma catecholamines, and urinary catecholamines and to assess their variability.

Methods  Plasma metanephrine as well as plasma and urinary catecholamine concentrations were measured by high-performance liquid chromatography with electrochemical detection. Before surgery, responses of plasma metanephrines and catecholamines to change of posture were determined. Intraoperatively, metanephrines and catecholamines were measured before skin incision, during maximal mechanical tumor manipulation, and repetitively after the tumor was separated from the circulation. Patients were reexamined 1 and 3 months after surgery. Patients with pheochromocytoma (n = 17) and with histologically proved other adrenal tumors (n = 14) were studied before, during, and after surgery.

Results  Measurement of plasma metanephrines and plasma and urinary catecholamines provided 100% and 82% sensitivity, respectively, for the detection of pheochromocytoma (P<.001). Levels of plasma catecholamines but not metanephrines increased in response to change of posture (norepinephrine, P = .03; epinephrine, P = .07) and intraoperative stress (norepinephrine, P = .002; epinephrine, P = .009).

Conclusions  Plasma metanephrines offer improved efficacy for the diagnosis of pheochromocytoma. Less variability in response to external factors may favor plasma metanephrines in the screening for this disease.

From the Division of Endocrinology and Metabolism, Department of Medicine III (Drs Raber, Bischof, Gasic, Waldhäusl, and Roden and Mr Raffesberg), and the Department of Surgery (Drs Scheuba and Niederle), University of Vienna, Vienna, Austria.

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