 |
 |

Human Tissue Research in the Genomic Era of Medicine
Balancing Individual and Societal Interests
Ted T. Ashburn, MD, PhD;
Sharon K. Wilson, JD;
Barry I. Eisenstein, MD
Arch Intern Med. 2000;160:3377-3384.
Advances in DNA sequencing technology and in our understanding of the human genome are ushering in a new era of genomic medicine, one with dramatic potential to not only benefit society through research involving human tissue, but also to cause economic or psychosocial harms to tissue donors and their families. This delicate situation requires that the needs of tissue donors be carefully considered and balanced with those of the medical research community, especially on issues concerning confidentiality, consent, and compensation. We analyzed the tensions between tissue donors and researchers over the research use of human tissue. We also reviewed several approaches, including the establishment of tissue-trustee infrastructures at academic medical centers, aimed at achieving a more equitable balance between individual donor protection and societal benefits derived from tissue-based research.
From Pfizer Inc, Groton, Conn (Dr Ashburn); Office of Science and Technology, Beth Israel Deaconess Medical Center, Boston, Mass (Drs Wilson and Eisenstein); and Harvard Medical School, Boston (Drs Ashburn and Eisenstein). Dr Ashburn is currently employed full time by Pfizer Inc.
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Researchers' preferences and attitudes on ethical aspects of genomics research: a comparative study between the USA and Spain
Ruiz-Canela et al.
J. Med. Ethics 2009;35:251-257.
ABSTRACT
| FULL TEXT
Opt-out plus, the patients' choice: preferences of cancer patients concerning information and consent regimen for future research with biological samples archived in the context of treatment
Vermeulen et al.
J. Clin. Pathol. 2009;62:275-278.
ABSTRACT
| FULL TEXT
Human-tissue-related inventions: ownership and intellectual property rights in international collaborative research in developing countries
Andanda
J. Med. Ethics 2008;34:171-179.
ABSTRACT
| FULL TEXT
Ethical and legal issues in research involving human subjects: do you want a piece of me?
Kapp
J. Clin. Pathol. 2006;59:335-339.
ABSTRACT
| FULL TEXT
The Ethics of Research Using Biobanks: Reason to Question the Importance Attributed to Informed Consent
Hoeyer et al.
Arch Intern Med 2005;165:97-100.
ABSTRACT
| FULL TEXT
The Charitable Trust as a Model for Genomic Biobanks
Winickoff and Winickoff
NEJM 2003;349:1180-1184.
FULL TEXT
The Case for Compensation of Tissue Donors
Tavar et al.
Arch Intern Med 2001;161:1924-1925.
FULL TEXT
|