This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (500)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal

A Multicenter Survey to Evaluate the Percentages of Dyslipidemic Patients Receiving Lipid-Lowering Therapy and Achieving Low-Density Lipoprotein Cholesterol Goals

Thomas A. Pearson, MD, PhD, MPH; Irene Laurora, PharmD; Henry Chu, MS; Stephanie Kafonek, MD

Arch Intern Med. 2000;160:459-467.

Objective  To determine the percentage of patients in the multicenter Lipid Treatment Assessment Project receiving lipid-lowering therapy who are achieving low-density lipoprotein cholesterol (LDL-C) goals as defined by National Cholesterol Education Program (NCEP) guidelines.

Methods  Adult patients with dyslipidemia, who had been receiving the same lipid-lowering therapy for at least 3 months, were assessed at investigation sites. Lipid levels were determined once in each patient at the time of enrollment. The primary end point was the success rate, defined as the proportion of patients who achieved their LDL-C target level as specified by NCEP guidelines.

Results  A total of 4888 patients from 5 regions of the United States were studied. Of these, 23% had fewer than 2 risk factors for coronary heart disease (CHD) and no evidence of CHD (low-risk group), 47% had 2 or more risk factors and no evidence of CHD (high-risk group), and 30% had established CHD. Overall, only 38% of patients achieved NCEP-specified LDL-C target levels; success rates were 68% among low-risk patients, 37% among high-risk patents, and 18% among patients with CHD. Drug therapy was significantly (P.001) more effective than nondrug therapy in all patient risk groups. However, many patients treated with lipid-lowering drugs did not achieve LDL-C target levels.

Conclusions  Large proportions of dyslipidemic patients receiving lipid-lowering therapy are not achieving NCEP LDL-C target levels. These findings indicate that more aggressive treatment of dyslipidemia is needed to attain goals established by NCEP guidelines.

From the Department of Community and Preventive Medicine, University of Rochester School of Medicine, Rochester, NY (Dr Pearson); and Parke-Davis Co, Morris Plains, NJ (Drs Laurora and Kafonek and Mr Chu).

RELATED ARTICLE

Archives of Internal Medicine Reader's Choice: Continuing Medical Education
Arch Intern Med. 2000;160(4):555-556.
FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Achieving Vascular Risk Factor Targets: A Survey of a London General Practice
Levine et al.
ANGIOLOGY 2008;59:36-46.
ABSTRACT  

Strategies for prescribing statins
Donner-Banzhoff and Sonnichsen
BMJ 2008;336:288-289.
FULL TEXT  

Using Computer-Based Decision Support to Close the "Know Do" Gap in Lipid-Lowering Therapy
Avorn and Choudhry
Circulation 2008;117:336-337.
FULL TEXT  

Achievement of guideline-defined treatment goals in primary care: the German Coronary Risk Management (CoRiMa) study
Geller et al.
Eur Heart J 2007;28:3051-3058.
ABSTRACT | FULL TEXT  

Patient Knowledge of Coronary Risk Profile Improves the Effectiveness of Dyslipidemia Therapy: The CHECK-UP Study: A Randomized Controlled Trial
Grover et al.
Arch Intern Med 2007;167:2296-2303.
ABSTRACT | FULL TEXT  

Patterns and predictors of statin use after coronary artery bypass graft surgery.
Kulik et al.
J. Thorac. Cardiovasc. Surg. 2007;134:932-938.
ABSTRACT | FULL TEXT  

Atherosclerosis Secondary Prevention Performance Measures After Coronary Bypass Graft Surgery Compared With Percutaneous Catheter Intervention and Nonintervention Patients in the Get With the Guidelines Database
Hiratzka et al.
Circulation 2007;116:I-207-I-212.
ABSTRACT | FULL TEXT  

Are patients with hyperlipidemia undertreated?: Study of patients admitted to hospital with coronary events
Lipson et al.
cfp 2007;53:1502-1507.
ABSTRACT | FULL TEXT  

Reduction in Estimated Risk for Coronary Artery Disease After Use of Ezetimibe with a Statin
Sampalis et al.
The Annals of Pharmacotherapy 2007;41:1345-1351.
ABSTRACT | FULL TEXT  

Use of maximum-dose simvastatin or atorvastatin in an ethnically diverse population
Song et al.
Am J Health Syst Pharm 2007;64:767-772.
ABSTRACT | FULL TEXT  

Coronary Heart Disease in Patients With Diabetes: Part I: Recent Advances in Prevention and Noninvasive Management
Berry et al.
J Am Coll Cardiol 2007;49:631-642.
ABSTRACT | FULL TEXT  

Rational therapy of mixed dyslipidaemia in a patient with diabetes
Reasner
British Journal of Diabetes & Vascular Disease 2007;7:25-30.
ABSTRACT  

Ensuring that Patients Receive Full Cardiac Pharmacotherapy Services: A Pharmacist's Call to Arms
White
The Annals of Pharmacotherapy 2006;40:2248-2250.
ABSTRACT | FULL TEXT  

The Natural History of LDL Control in Type 2 Diabetes: A prospective study of adherence to lipid guidelines.
Rucker et al.
Diabetes Care 2006;29:2506-2508.
FULL TEXT  

Efficacy and Safety of Rosuvastatin Every Other Day Compared with Once Daily in Patients with Hypercholesterolemia
Wongwiwatthananukit et al.
The Annals of Pharmacotherapy 2006;40:1917-1923.
ABSTRACT | FULL TEXT  

The gap between theory and practice: what do the trials tell us?
Pedersen
Eur Heart J Suppl 2006;8:F10-F16.
ABSTRACT | FULL TEXT  

Evaluation of patient and provider satisfaction with a pharmacist-managed lipid clinic in a Veterans Affairs medical center.
Collins et al.
Am J Health Syst Pharm 2006;63:1723-1727.
ABSTRACT | FULL TEXT  

Food Does Not Affect the Pharmacokinetics of Tesaglitazar, a Novel Dual Peroxisome Proliferator-Activated Receptor {alpha}/{gamma} Agonist.
Samuelsson et al.
J Clin Pharmacol 2006;46:1017-1022.
ABSTRACT | FULL TEXT  

Introduction: Pharmacotherapy for Dyslipidemia
Dumo
Journal of Pharmacy Practice 2006;19:61-62.
 

Role of the Pharmacist in the Management of Dyslipidemia
Olson and Potts
Journal of Pharmacy Practice 2006;19:94-102.
ABSTRACT  

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Council on Stroke: Co-Sponsored by the Council on Cardiovascular Radiology and Intervention: The American Academy of Neurology affirms the value of this guideline.
Sacco et al.
Circulation 2006;113:e409-e449.
ABSTRACT | FULL TEXT  

An Intervention to Overcome Clinical Inertia and Improve Diabetes Mellitus Control in a Primary Care Setting: Improving Primary Care of African Americans With Diabetes (IPCAAD) 8.
Ziemer et al.
Arch Intern Med 2006;166:507-513.
ABSTRACT | FULL TEXT  

Dyslipidemia Prevalence, Treatment, and Control in the Multi-Ethnic Study of Atherosclerosis (MESA): Gender, Ethnicity, and Coronary Artery Calcium
Goff et al.
Circulation 2006;113:647-656.
ABSTRACT | FULL TEXT  

Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Council on Stroke: Co-Sponsored by the Council on Cardiovascular Radiology and Intervention: The American Academy of Neurology affirms the value of this guideline.
Sacco et al.
Stroke 2006;37:577-617.
ABSTRACT | FULL TEXT  

AUDIT study. Evidence of global undertreatment of dyslipidaemia in patients with type 2 diabetes mellitus
Leiter et al.
British Journal of Diabetes & Vascular Disease 2006;6:31-40.
ABSTRACT  

Family Physician's Knowledge, Beliefs, and Self-reported Practice Patterns Regarding Hyperlipidemia: A National Research Network (NRN) Survey
Eaton et al.
J Am Board Fam Med 2006;19:46-53.
ABSTRACT | FULL TEXT  

Determinants of the Differences in LDL-Cholesterol After Initiation of Statin Treatment
Caspard et al.
The Annals of Pharmacotherapy 2006;40:21-26.
ABSTRACT | FULL TEXT  

Managing Abnormal Blood Lipids: A Collaborative Approach
Fletcher et al.
Circulation 2005;112:3184-3209.
ABSTRACT | FULL TEXT  

The contrOL of dYslipideMia in outPatIent clinics in GreeCe (Olympic) Study
Diamantopoulos et al.
ANGIOLOGY 2005;56:731-741.
ABSTRACT  

Lipids and CVD management: towards a global consensus
Ballantyne et al.
Eur Heart J 2005;26:2224-2231.
ABSTRACT | FULL TEXT  

Managing cardiovascular risk: reality vs. perception
Erhardt
Eur Heart J Suppl 2005;7:L11-L15.
ABSTRACT | FULL TEXT  

Goal attainment in patients referred to a telephone-based dyslipidemia program
Palmieri et al.
Am J Health Syst Pharm 2005;62:1586-1591.
ABSTRACT | FULL TEXT  

Association between short-term effectiveness of statins and long-term adherence to lipid-lowering therapy
Benner et al.
Am J Health Syst Pharm 2005;62:1468-1475.
ABSTRACT | FULL TEXT  

Over-the-Counter Statins
Choudhry and Avorn
ANN INTERN MED 2005;142:910-913.
ABSTRACT | FULL TEXT  

The Challenge of Achieving National Cholesterol Goals in Patients With Diabetes
Kennedy et al.
Diabetes Care 2005;28:1029-1034.
ABSTRACT | FULL TEXT  

Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease
Hopkins et al.
J Am Coll Cardiol 2005;45:1003-1012.
ABSTRACT | FULL TEXT  

Adherence to Statin Therapy and LDL Cholesterol Goal Attainment by Patients With Diabetes and Dyslipidemia
Parris et al.
Diabetes Care 2005;28:595-599.
ABSTRACT | FULL TEXT  

Statin Initiation Following Coronary Artery Bypass Grafting: Outcome of a Hospital Discharge Protocol
Khanderia et al.
Chest 2005;127:455-463.
ABSTRACT | FULL TEXT  

Opportunity for Intervention to Achieve American Heart Association Guidelines for Optimal Lipid Levels in High-Risk Women in a Managed Care Setting
Mosca et al.
Circulation 2005;111:488-493.
ABSTRACT | FULL TEXT  

National Study of Physician Awareness and Adherence to Cardiovascular Disease Prevention Guidelines
Mosca et al.
Circulation 2005;111:499-510.
ABSTRACT | FULL TEXT  

Is Lipid-Lowering Therapy Underused by African Americans at High Risk of Coronary Heart Disease Within the VA Health Care System?
Woodard et al.
Am. J. Public Health 2004;94:2112-2117.
ABSTRACT | FULL TEXT  

Coadministration Therapy in Hypercholesterolemia: A Novel Approach to Achieving Lipid Goals--Introduction
Chilton
JAOA: Journal of the American Osteopathic Association 2004;104:3S-4S.
FULL TEXT  

Coadministration of Multidrug Therapy to Achieve Lipid Goals
Denke
JAOA: Journal of the American Osteopathic Association 2004;104:17S-22S.
ABSTRACT | FULL TEXT  

Guidelines and management of global risk: the European perspective
Hobbs
Eur Heart J Suppl 2004;6:C5-C14.
ABSTRACT | FULL TEXT  

The cardiologist's toolbox: improving care
Ben-Yehuda
J Am Coll Cardiol 2004;43:2174-2176.
FULL TEXT  

Compliance with Recommendations for Lipid Management among Patients with Type 2 Diabetes in an Academic Family Practice
Putzer et al.
J Am Board Fam Med 2004;17:101-107.
ABSTRACT | FULL TEXT  

Reducing low-density lipoprotein cholesterol - treating to target and meeting new European goals
Kritharides
Eur Heart J Suppl 2004;6:A12-A18.
ABSTRACT | FULL TEXT  

Lipid management in the proteinuric patient: do not overlook the importance of proteinuria reduction
Vogt et al.
Nephrol Dial Transplant 2004;19:5-8.
FULL TEXT  

In-Hospital Initiation of Lipid-Lowering Therapy After Coronary Intervention as a Predictor of Long-term Utilization: A Propensity Analysis
Aronow et al.
Arch Intern Med 2003;163:2576-2582.
ABSTRACT | FULL TEXT  

Review: Diabetic dyslipidaemia -- the case for using statins
Gadsby
British Journal of Diabetes & Vascular Disease 2003;3:402-407.
ABSTRACT  

Aggressive Lipid Management for Cardiovascular Prevention: Evidence from Clinical Trials
Friday
Exp. Biol. Med. 2003;228:769-778.
ABSTRACT | FULL TEXT  

Task force #1--identification of coronary heart disease risk: is there a detection gap?
Pasternak et al.
J Am Coll Cardiol 2003;41:1863-1874.
FULL TEXT  

Foreword
Pedersen and Stein
Eur Heart J Suppl 2003;5:D1-D2.
 

Low-density lipoprotein cholesterol targets in 2003
Faergeman
Eur Heart J Suppl 2003;5:D3-D7.
ABSTRACT  

Effect of Ezetimibe Coadministered With Atorvastatin in 628 Patients With Primary Hypercholesterolemia: A Prospective, Randomized, Double-Blind Trial
Ballantyne et al.
Circulation 2003;107:2409-2415.
ABSTRACT | FULL TEXT  

An Evaluation of Cholesterol Management Within a State Correctional System
LaForest and Algozzine
JOURNAL OF CORRECTIONAL HEALTH CARE 2003;10:75-87.
ABSTRACT  

Trends in Lipid Management Among Patients With Coronary Artery Disease: Has diabetes received the attention it deserves?
Massing et al.
Diabetes Care 2003;26:991-997.
ABSTRACT | FULL TEXT  

Secondary prevention after coronary bypass: the American Heart Association "Get with the Guidelines" program
Denton et al.
Ann. Thorac. Surg. 2003;75:758-760.
FULL TEXT  

The Challenge of Balancing Scientific Discovery and Translation
Bonow
Circulation 2003;107:358-362.
FULL TEXT  

Cardiovascular Disease in Type 2 Diabetes Mellitus: Current Management Guidelines
Mooradian
Arch Intern Med 2003;163:33-40.
ABSTRACT | FULL TEXT  

Acceptance of guideline recommendations and perceived implementation of coronary heart disease prevention among primary care physicians in five European countries: the Reassessing European Attitudes about Cardiovascular Treatment (REACT) survey
Hobbs and Erhardt
Fam Pract 2002;19:596-604.
ABSTRACT | FULL TEXT  

Combination therapy: its rationale and the role of ezetimibe
Stone
Eur Heart J Suppl 2002;4:J19-J22.
ABSTRACT  

The New National Cholesterol Education Program Guidelines: Clinical Challenges for More Widespread Therapy of Lipids to Treat and Prevent Coronary Heart Disease
Eidelman et al.
Arch Intern Med 2002;162:2033-2036.
FULL TEXT  

Guidelines and global risk: a U.S. perspective
Gotto
Eur Heart J Suppl 2002;4:F7-F11.
ABSTRACT  

What should cardiologists be telling general practitioners/family physicians?
Hobbs
Eur Heart J Suppl 2002;4:F54-F59.
ABSTRACT  

Task Force #4--adherence issues and behavior changes: achieving a long-term solution
Ockene et al.
J Am Coll Cardiol 2002;40:630-640.
FULL TEXT  

Treating to goal: new strategies for initiating and optimizing lipid-lowering therapy in patients with atherosclerosis
Fonarow
Vasc Med 2002;7:187-194.
ABSTRACT  

Impact of availability and use of coronary interventions on the prescription of aspirin and lipid lowering treatment after acute coronary syndromes
Steg et al.
Heart 2002;88:20-24.
ABSTRACT | FULL TEXT  

Use of Statins and Aspirin to Reduce Risks of Cardiovascular Disease
Hebert et al.
J CARDIOVASC PHARMACOL THER 2002;7:77-80.
 

A Randomized Trial of the Effect of Community Pharmacist Intervention on Cholesterol Risk Management: The Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP)
Tsuyuki et al.
Arch Intern Med 2002;162:1149-1155.
ABSTRACT | FULL TEXT  

Use of Cholesterol-Lowering Therapy by Elderly Adults After Myocardial Infarction
Ayanian et al.
Arch Intern Med 2002;162:1013-1019.
ABSTRACT | FULL TEXT  

Disposition of the Selective Cholesterol Absorption Inhibitor Ezetimibe in Healthy Male Subjects
Patrick et al.
Drug Metab. Dispos. 2002;30:430-437.
ABSTRACT | FULL TEXT  

New Tools for Coronary Risk Assessment: What Are Their Advantages and Limitations?
Pearson
Circulation 2002;105:886-892.
ABSTRACT | FULL TEXT  

The Impact of Outpatient Diabetes Management on Serum Lipids in Urban African-Americans With Type 2 Diabetes
Erdman et al.
Diabetes Care 2002;25:9-15.
ABSTRACT | FULL TEXT  

Lipid Disorders : Justification of Methods and Goals of Treatment
Braunstein et al.
Chest 2001;120:979-988.
ABSTRACT | FULL TEXT  

Translation of nutritional sciences into medical education: the Nutrition Academic Award Program
Pearson et al.
Am. J. Clin. Nutr. 2001;74:164-170.
ABSTRACT | FULL TEXT  

In-Hospital Initiation of Lipid-Lowering Therapy for Patients With Coronary Heart Disease : The Time Is Now
Fonarow and Ballantyne
Circulation 2001;103:2768-2770.
FULL TEXT  

Cholesterol absorption inhibition: filling an unmet need in lipid-lowering management
Leitersdorf
Eur Heart J Suppl 2001;3:E17-E23.
ABSTRACT  

Introduction
Kastelein and Shepherd
Eur Heart J Suppl 2001;3:B1-B2.
 

Primary Prevention of Coronary Heart Disease: Where Do We Go From Here?
Gotto
Arch Intern Med 2001;161:922-924.
FULL TEXT  

Improving Lipid Evaluation and Management in Medicare Patients Hospitalized for Acute Myocardial Infarction
Malach et al.
Arch Intern Med 2001;161:839-844.
ABSTRACT | FULL TEXT  

Trends and Disparities in Coronary Heart Disease, Stroke, and Other Cardiovascular Diseases in the United States : Findings of the National Conference on Cardiovascular Disease Prevention
Cooper et al.
Circulation 2000;102:3137-3147.
ABSTRACT | FULL TEXT