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Unresolved Issues in the Role of Cyclooxygenase-2 in Normal Physiologic Processes and Disease
Peter E. Lipsky, MD;
Peter Brooks, MD;
Leslie J. Crofford, MD;
Raymond DuBois, MD, PhD;
David Graham, MD;
Lee S. Simon, MD;
Leo B. A. van de Putte, MD, PhD, FRCP;
Steven B. Abramson, MD
Arch Intern Med. 2000;160:913-920.
Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2–specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.
From the University of Texas Southwestern Medical Center, Dallas (Dr Lipsky); The University of Queensland, Brisbane, Australia (Dr Brooks); University of Michigan Medical Center, Ann Arbor (Dr Crofford); Vanderbilt University Medical Center, Nashville, Tenn (Dr DuBois); Veterans Affairs Medical Center Houston, Houston, Tex (Dr Graham); Harvard Medical School, Boston, Mass (Dr Simon); University Hospital Nijmegen, Nijmegen, the Netherlands (Dr van de Putte); and New York University School of Medicine, New York, NY (Dr Abramson).
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