The Diagnosis of Glomerular Diseases
Acute Glomerulonephritis and the Nephrotic Syndrome
Michael P. Madaio, MD;
John T. Harrington, MD
Arch Intern Med. 2001;161:25-34.
Rapid and efficient diagnosis of diseases presenting as acute glomerulonephritis
and/or nephrotic syndrome is critical for early and appropriate therapy aimed
at preservation of renal function. Although there may be overlap in clinical
presentation, and some patients present with clinical features of both syndromes,
this analysis serves as an initial framework to proceed with serologic testing
and/or pathologic confirmation en route to final diagnosis. Efficient and
timely diagnosis is essential in these situations because progression to end-stage
renal disease may result if the underlying disease is not promptly treated.
From the Renal Electrolyte and Hypertension Division, Department of
Medicine, University of Pennsylvania, Philadelphia (Dr Madaio), and the Nephrology
Division, Department of Medicine, New England Medical Center and Tufts University
School of Medicine, Boston, Mass (Dr Harrington).
Corresponding author and reprints: Michael P. Madaio, MD, University
of Pennsylvania Medical Center, Renal Electrolyte and Hypertension Division,
700 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, PA 19104-6144 (e-mail: Madaio{at}mail.med.upenn.edu).
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