 |
|
The Effect of Hormone Replacement Therapy on Cardiovascular Risk Factors in Type 2 Diabetes
A Randomized Controlled Trial
Patrick J. Manning, MBChB, MMedSc, FRACP;
Anne Allum, EN;
Shirley Jones, RN;
Wayne H. F. Sutherland, PhD;
Sheila M. Williams, BSc(Hons)
Arch Intern Med. 2001;161:1772-1776.
Background Postmenopausal women with diabetes are at high risk for cardiovascular
disease, compared with their nondiabetic counterparts. Combined continuous
hormone replacement therapy (HRT) is associated with improvements in serum
lipoprotein levels in nondiabetic women; however, the effect in women with
diabetes has not been determined. We evaluated the effect of combined continuous
HRT on lipoprotein and coagulation factor concentrations and glycemic control
in postmenopausal women with type 2 diabetes mellitus.
Methods In a randomized controlled crossover study, 61 subjects received combined
continuous HRT or placebo. Each treatment phase was of 6 months' duration,
with an 8-week washout phase between treatment phases.
Results Total cholesterol concentration decreased by 7% (95% confidence interval
[CI], 4%-11%) during HRT. For low-density lipoprotein concentration, the mean
decrease with HRT was 12% (95% CI, 6%-17%). Apolipoprotein B levels decreased
in keeping with the reduction in low-density lipoprotein cholesterol concentrations.
There were no significant changes in concentrations of high-density lipoprotein,
its subfractions, or triglycerides. Lipoprotein(a) and fibrinogen concentrations
were reduced by 21% (95% CI, 10%-31%) and 8% (95% CI, 2%-13%), respectively,
with HRT. Fructosamine concentrations declined by 5% (95% CI, 2%-9%) during
HRT.
Conclusions In postmenopausal women with type 2 diabetes mellitus, combined continuous
HRT has beneficial effects on lipoprotein concentrations and improves some
markers of coagulation and glycemic control.
From the Departments of Medicine (Drs Manning and Sutherland and Mss
Allum and Jones) and Preventive and Social Medicine (Ms Williams), School
of Medicine, University of Otago, Dunedin, New Zealand.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
Archives of Internal Medicine Reader's Choice: Continuing Medical Education
Arch Intern Med. 2001;161(14):1783-1784.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Postmenopausal Hormone Therapy Is Associated With Atherosclerosis Progression in Women With Abnormal Glucose Tolerance
Howard et al.
Circulation 2004;110:201-206.
ABSTRACT
| FULL TEXT
Estrogen Therapy and Risk of Cardiovascular Events Among Women With Type 2 Diabetes
Newton et al.
Diabetes Care 2003;26:2810-2816.
ABSTRACT
| FULL TEXT
Effects of short-term transdermal hormone replacement therapy on glycaemic control, lipid metabolism, C-reactive protein and proteinuria in postmenopausal women with type 2 diabetes or hypertension
Fenkci et al.
Hum Reprod 2003;18:866-870.
ABSTRACT
| FULL TEXT
Glycemic Effects of Postmenopausal Hormone Therapy: The Heart and Estrogen/progestin Replacement Study: A Randomized, Double-Blind, Placebo-Controlled Trial
Kanaya et al.
ANN INTERN MED 2003;138:1-9.
ABSTRACT
| FULL TEXT
Hormone Replacement Therapy and Its Relationship to Lipid and Glucose Metabolism in Diabetic and Nondiabetic Postmenopausal Women: Results from the Third National Health and Nutrition Examination Survey (NHANES III)
Crespo et al.
Diabetes Care 2002;25:1675-1680.
ABSTRACT
| FULL TEXT
Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group IV: Lifestyle and Medical Management of Risk Factors
Grundy et al.
Circulation 2002;105
:e153-e158.
FULL TEXT
Hormone Replacement Therapy and Glycemic Control: Evidence from Observational Studies and Randomized Clinical Trials: Response to Dr. Aquilar-Salinas et al.
Ferrara et al.
Diabetes Care 2002;25:246-247.
FULL TEXT
|
