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Severe Orthostatic Hypotension Following Weight Reduction Surgery
Ronen Rubinshtein, MD;
Mishu Ciubotaru, MD;
Hadar Elad, MD;
Haim Bitterman, MD
Arch Intern Med. 2001;161:2145-2147.
Surgical interventions for morbid obesity are common practice in many
countries, especially when other treatment options have failed or when rapid
weight loss is desired. The association between weight and blood pressure
is well established, especially the paradigm of obesity-related hypertension.
We describe a 45-year-old obese woman with a medical history of hypertension
and type 2 diabetes mellitus who lost 57 kg within a few months after a weight
reduction surgery. She suffered from severe orthostatic hypotension, which
probably resulted from sympathetic nervous system dysfunction. Our patient's
clinical status improved with pharmacological interventions, but her symptoms
resolved completely after she gained weight following a surgical reversal
of the gastric partitioning owing to a local complication. Autonomic nervous
system activity does change with the changes in body weight, but after evaluation
of this patient, we believe that rapid weight loss may impair sympathetic
function and blood pressure control. Although losing weight is a known treatment
option for hypertension, exaggerated reversal of obesity-related hypertension
might result in orthostatic hypotension.
From the Department of Internal Medicine A, Carmel Medical Center,
and the Rappaport Family Institute, Faculty of Medicine, Technion-Israel Institute
of Technology, Haifa, Israel.
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