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Blood Pressure, Cognitive Functions, and Prevention of Dementias in Older Patients With Hypertension
Willem H. Birkenhäger, MD, PhD;
Françoise Forette, MD, PhD;
Marie-Laure Seux, MD;
Ji-Guang Wang, MD;
Jan A. Staessen, MD, PhD
Arch Intern Med. 2001;161:152-156.
The prevalence and incidence of degenerative and vascular dementias
increase exponentially with age, from 70 years onward. In view of the increasing
longevity of humans, both varieties are bound to evolve into a major problem
worldwide. According to several longitudinal studies, hypertension appears
to predispose individuals to the development of cognitive impairment and ensuing
dementia, after a period varying from a few years to several decades. Antihypertensive
drug treatment, according to preliminary evidence, may serve to reduce the
rates of such events. Such findings await to be confirmed by formal therapeutic
trials against a backdrop of "historical" observational sources.
From the Faculty of Medicine, Erasmus University Rotterdam, Rotterdam,
the Netherlands (Dr Birkenhäger); the Department of Geriatrics, Broca
Hospital, Centre Hospitalier Universitaire Cochin, University of Paris V,
Paris, France (Drs Forette and Seux); and the Studiecoördinatiecentrum,
Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement Moleculair
en Cardiovasculair Onderzoek, Katholieke Universiteit Leuven, Leuven, Belgium
(Drs Wang and Staessen).
Corresponding author and reprints: Jan A. Staessen, MD, PhD, Studiecoördinatiecentrum,
Laboratorium Hypertensie, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven,
Belgium (e-mail: jan.staessen{at}med.kuleuven.ac.be).
RELATED LETTER
Increased Blood Pressure Variability May Be Associated With Cognitive Decline in Hypertensive Elderly Subjects With No Dementia
Giuseppe Bellelli, Alessandra Pezzini, Angelo Bianchetti, Marco Trabucchi, Willem H. Birkenhäger, Françoise Forette, Marie-Laure Seux, Lutgarde Thijs, and Jan A. Staessen
Arch Intern Med. 2002;162(4):483-484.
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