 |
|
Cost-Benefit Analysis of a Strategy to Vaccinate Healthy Working Adults Against Influenza
Kristin L. Nichol, MD, MPH, MBA
Arch Intern Med. 2001;161:749-759.
Background Influenza is a major cause of illness, disruption to daily life, and
work absenteeism among healthy working adults aged between 18 and 64 years.
This group is not included among the traditional priority groups for annual
vaccination. Immunization rates remain low.
Objective To assess the economic implications of a strategy for annual vaccination
of this group.
Methods Using the societal perspective, this cost-benefit analysis included
the direct and indirect costs associated with vaccination as well as the direct
and indirect costs prevented by vaccination. Clinical and economic variable
estimates were derived primarily from the published literature. For this model,
it was assumed that vaccination occurred in efficient, low-cost settings such
as at the work site. Monte Carlo simulation was used to calculate the mean
net costs or savings along with the 95% probability interval, and sensitivity
analyses explored the sensitivity of the cost model to different values of
the input variables.
Results Vaccinating healthy working adults was on average cost saving, with
mean savings of $13.66 per person vaccinated (95% probability interval: net
savings of $32.97 to net costs of $2.18), with vaccination generating net
savings 95% of the time. The model was most sensitive to the influenza illness
rate, the work absenteeism rate due to influenza, and hourly wages. In the
worst-case scenario vaccination was not cost saving. Vaccination also generated
net costs to society during years with a poor vaccine–circulating virus
strain match. In all of the other sensitivity analysis scenarios, vaccination
was cost saving.
Conclusion Influenza vaccination of healthy working adults on average is cost saving.
These findings support a strategy of routine, annual vaccination for this
group, especially when vaccination occurs in efficient and low-cost sites.
From the Center for Chronic Disease Outcomes Research and Medicine
Service, Veterans Affairs Medical Center and University of Minnesota Medical
School, Minneapolis. Dr Nichol has received research funds from infuenza vaccine
manufacturers.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Seasonal Influenza: An Overview
Li and Freedman
The Journal of School Nursing 2009;25:4S-12S.
ABSTRACT
| FULL TEXT
Half- vs Full-Dose Trivalent Inactivated Influenza Vaccine (2004-2005): Age, Dose, and Sex Effects on Immune Responses
Engler et al.
Arch Intern Med 2008;168:2405-2414.
ABSTRACT
| FULL TEXT
Improving Immunization Rates: Initial Results From a Team-Based, Systems Change Approach
Reynolds et al.
American Journal of Medical Quality 2008;23:176-183.
ABSTRACT
Preattack Vaccination Against Anthrax May Be Cost-effective in Certain Populations
Hopkins et al.
Arch Intern Med 2008;168:114-115.
FULL TEXT
Public health and business: a partnership that makes cents.
Simon and Fielding
Health Aff (Millwood) 2006;25:1029-1039.
ABSTRACT
| FULL TEXT
The guinea pig as a transmission model for human influenza viruses
Lowen et al.
Proc. Natl. Acad. Sci. USA 2006;103:9988-9992.
ABSTRACT
| FULL TEXT
Guidelines for the management of adult lower respiratory tract infections
Woodhead et al.
Eur Respir J 2005;26:1138-1180.
ABSTRACT
| FULL TEXT
Does This Patient Have Influenza?
Call et al.
JAMA 2005;293:987-997.
ABSTRACT
| FULL TEXT
Influenza Vaccination in Elderly Patients With Advanced Colorectal Cancer
Earle
JCO 2003;21:1161-1166.
ABSTRACT
| FULL TEXT
Economic Analysis of Influenza Vaccination and Antiviral Treatment for Healthy Working Adults
Lee et al.
ANN INTERN MED 2002;137:225-231.
ABSTRACT
| FULL TEXT
Review: inactivated vaccines provide the greatest protection against influenza in healthy people
Gross
Evid. Based Med. 2002;7:75-75.
FULL TEXT
Influenza Vaccination for Healthy Young Adults
Ahmed et al.
NEJM 2001;345:1543-1547.
FULL TEXT
|
